Protein Ontology Report - hTIRAP PR:P58753 - http://purl.obolibrary.org/obo/PR_P58753

This page represents a class of proteins encompassing all the protein products of the TIRAP gene in human .

Ontology Information
PRO ID	PR:P58753 Show OBO stanza / PAF
PRO name	Toll/interleukin-1 receptor domain-containing adapter protein (human)
Synonyms	PRO-short-label: hTIRAP EXACT: MyD88 adapter-like protein (human); MyD88-2 (human); TIR domain-containing adapter protein (human); adaptor protein Wyatt (human) Gene-based: MAL; TIRAP
Definition	A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:17192, Reactome:R-HSA-166141, UniProtKB:P58753

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTIRAP forms found in complexes

hTIRAP Component Complexes PR:000001751 TIRAP PR:000036006 TIRAP:PIP2 complex PR:000001751 TIRAP PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex PR:000001751 TIRAP PR:000025784 MYD88:TIRAP:activated TLR4 receptor PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human) PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:000027214 hTIRAP/iso:1/Phos:1 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) PR:P58753 hTIRAP PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) PR:P58753 hTIRAP PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) PR:P58753 hTIRAP PR:000036014 TIRAP:PIP2 complex (human) PR:P58753-1 hTIRAP/iso:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) PR:P58753-1 hTIRAP/iso:1 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) PR:P58753-1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000001751 TIRAP has_part Pfam:PF01582 TIR domain PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) located_in GO:0005886 plasma membrane Reactome:REACT_152404 participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 PR:P58753-2 hTIRAP/iso:2 capable_of GO:0005546 phosphatidylinositol-4,5-bisphosphate binding PMID:24529375 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) located_in GO:0005886 plasma membrane Reactome:REACT_125282 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282 participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282 PR:000036014 TIRAP:PIP2 complex (human) located_in GO:0005886 plasma membrane Reactome:REACT_151450 participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) capable_of GO:0004713 protein tyrosine kinase activity Reactome:REACT_120882 located_in GO:0005886 plasma membrane Reactome:REACT_120882 participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036014 TIRAP:PIP2 complex (human) Reactome:REACT_25222 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) Reactome:REACT_25222 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282 GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human) Reactome:REACT_6894 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human) Reactome:REACT_6894 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) Reactome:REACT_6894 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005886 plasma membrane PR:000036014 TIRAP:PIP2 complex (human) Reactome:REACT_151450 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human) Reactome:REACT_152404 PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_120882 PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human) Reactome:REACT_125282

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