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Protein Ontology Report - hLEFTY2

PR:O00292 - http://purl.obolibrary.org/obo/PR_O00292
This page represents a class of proteins encompassing all the protein products of the LEFTY2 gene in human .
Ontology Information
PRO ID PR:O00292 Show OBO stanza / PAF
PRO name left-right determination factor 2 (human)
Synonyms
PRO-short-label: hLEFTY2
EXACT: TGF-beta-4 (human); endometrial bleeding-associated factor (human); left-right determination factor A (human); protein lefty-2 (human); protein lefty-A (human); transforming growth factor beta-4 (human)
Gene-based: EBAF; LEFTA; LEFTY2; LEFTYA; PSEC0024; TGFB4
Definition A lefty 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O00292]
PRO Category organism-gene
Parent PR:000000288 lefty 2
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 3
organism-modification 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000452
hLEFTY2/var:S342N
Ser-342, CHEBI:50347 		associated_with_disease_progression DOID:0050545 visceral heterotaxy PMID:10053005
PR:O00292-1
hLEFTY2/iso:1
participates_in GO:0007309 oocyte axis specification PMID:10053005
participates_in GO:0007275 multicellular organism development PMID:10053005
PR:000036549
hLEFTY2/iso:1/Clv:1
located_in GO:0005615 extracellular space PMID:11278322
participates_in GO:0007275 multicellular organism development PMID:10053005
participates_in GO:0007309 oocyte axis specification PMID:10053005
PR:000036550
hLEFTY2/iso:1/Clv:2
located_in GO:0005615 extracellular space PMID:11278322
participates_in GO:0043406 positive regulation of MAP kinase activity PMID:11278322
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007309 oocyte axis specification PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:10053005
PR:O00292-1 hLEFTY2/iso:1

PMID:10053005
GO:0043406 positive regulation of MAP kinase activity PR:000036550 hLEFTY2/iso:1/Clv:2

PMID:11278322
GO:0007275 multicellular organism development PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:10053005
PR:O00292-1 hLEFTY2/iso:1

PMID:10053005
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2

PMID:11278322

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