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Protein Ontology Report - LEFTY2

PR:000000288 - http://purl.obolibrary.org/obo/PR_000000288
Ontology Information
PRO ID PR:000000288 Show OBO stanza / PAF
PRO name lefty 2
Synonyms
PRO-short-label: LEFTY2
EXACT: endometrial bleeding-associated factor; left-right determination factor A; protein lefty-2; protein lefty-A
Gene-based: EBAF; LEFTA; LEFTYA; PSEC0024; TGFB4
RELATED: Leftb; TGF-beta-4; left-right determination factor B; protein lefty-B; transforming growth factor beta-4
Definition A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000102 lefty protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 1
sequence 1 organism-sequence 4
modification 3 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000452
hLEFTY2/var:S342N
Ser-342, CHEBI:50347 		associated_with_disease_progression DOID:0050545 visceral heterotaxy PMID:10053005
PR:O00292-1
hLEFTY2/iso:1
participates_in GO:0007309 oocyte axis specification PMID:10053005
participates_in GO:0007275 multicellular organism development PMID:10053005
PR:000036549
hLEFTY2/iso:1/Clv:1
located_in GO:0005615 extracellular space PMID:11278322
participates_in GO:0007275 multicellular organism development PMID:10053005
participates_in GO:0007309 oocyte axis specification PMID:10053005
PR:000036550
hLEFTY2/iso:1/Clv:2
located_in GO:0005615 extracellular space PMID:11278322
participates_in GO:0043406 positive regulation of MAP kinase activity PMID:11278322
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007309 oocyte axis specification PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:10053005
PR:O00292-1 hLEFTY2/iso:1

PMID:10053005
GO:0043406 positive regulation of MAP kinase activity PR:000036550 hLEFTY2/iso:1/Clv:2

PMID:11278322
GO:0007275 multicellular organism development PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:10053005
PR:O00292-1 hLEFTY2/iso:1

PMID:10053005
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036549 hLEFTY2/iso:1/Clv:1

PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2

PMID:11278322

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