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Protein Ontology Report - DenV-polyprot

PR:000036816 - http://purl.obolibrary.org/obo/PR_000036816
Ontology Information
PRO ID PR:000036816 Show OBO stanza / PAF
PRO name dengue virus genome polyprotein
Synonyms
PRO-short-label: DenV-polyprot
Definition A protein that is a translation product of the dengue virus serotype 2 genomic RNA or a 1:1 ortholog thereof. [PRO:ES]
Comment Requested by=IDODEN. The dengue virus contains a 10.7 kb single-stranded RNA genome of positive strand polarity with a type I cap at the 5' terminus. The RNA genome is translated into a large glycosylated polyprotein precursor with proteins that are arranged in the order NH2-C-prM-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-COOH. Proteolytic processing in the region of the structural proteins is mediated by a host cell signal peptidase that is located within the endoplasmic reticulum. [PMID:12297031, PRO:ES]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 20
sequence 0 organism-sequence 0
modification 29 organism-modification 14
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

DenV-polyprot forms found in complexes
DenV-polyprot Component Complexes
PR:000036822 DenV-E PR:000036823 prM-E complex
PR:000036822 DenV-E PR:000036999 E protein dimer
PR:000036824 DenV-NS1 PR:000037002 NS1 dimer
PR:000036827 DenV-NS2B PR:000036829 NS2B-NS3 complex
PR:000036828 DenV-NS3 PR:000036829 NS2B-NS3 complex
PR:000036837 DenV-prM PR:000036823 prM-E complex
PR:000037000 DenV-NS1/sugar(+) PR:000037003 NS1 dimer, with complex sugar attached
PR:000037000 DenV-NS1/sugar(+) PR:000037005 NS1 hexamer, with complex sugar attached
PR:000037001 DenV-NS1/sugar(-) PR:000037004 NS1 dimer, without complex sugar unattached

Functional Annotation
PRO Term GO Annotation Evidence
PR:000044757
M (DEN26)
located_in GO:0019031 viral envelope PMID:14963133
participates_in GO:0046730 induction by virus of host immune response PMID:14963133
PR:000037002
NS1 dimer
located_in GO:0019034 viral replication complex PMID:8659120
participates_in GO:0019079 viral genome replication PMID:8659120
participates_in GO:0097281 immune complex formation PMID:8659120
PR:000044759
NS2A (DEN2N)
located_in GO:0019034 viral replication complex PMID:23408612
participates_in GO:0019076 viral release from host cell PMID:23408612
participates_in GO:0019068 virion assembly PMID:23408612
participates_in GO:0019079 viral genome replication PMID:23408612
PR:000036999
E protein dimer
capable_of GO:0046789 host cell surface receptor binding PMID:14963133
located_in GO:0019031 viral envelope PMID:14963133
participates_in GO:0019064 fusion of virus membrane with host plasma membrane PMID:14963133
PR:000037005
NS1 hexamer, with complex sugar attached
located_in GO:0005615 extracellular space PMID:8659120
PR:000036829
NS2B-NS3 complex
capable_of GO:0008236 serine-type peptidase activity PMID:23511634
capable_of GO:0008236 serine-type peptidase activity PMID:10744671
participates_in GO:0019082 viral protein processing PMID:10744671
participates_in GO:0019082 viral protein processing PMID:23511634
participates_in GO:0016540 protein autoprocessing PMID:23511634
PR:000044768
NS5 (DEN2N)
capable_of GO:0008168 methyltransferase activity PMID:21810535
capable_of GO:0003968 RNA-directed 5'-3' RNA polymerase activity PMID:21810535
capable_of GO:0070568 guanylyltransferase activity PMID:23408612
located_in GO:0019034 viral replication complex PMID:21810535
participates_in GO:0042783 evasion of host immune response PMID:21810535
participates_in GO:0019079 viral genome replication PMID:21810535
participates_in GO:0001510 RNA methylation PMID:21810535
PR:000044769
prM (DEN26)
Asn-183, MOD:00160 		capable_of GO:0044183 protein folding chaperone PMID:14963133
participates_in GO:0019068 virion assembly PMID:14963133
participates_in GO:0015031 protein transport PMID:14963133
PR:000044758
NS1 (DEN2N)
Asn-905/Asn-982, MOD:00160 		located_in GO:0019034 viral replication complex PMID:23408612
participates_in GO:0019079 viral genome replication PMID:23408612
participates_in GO:0097281 immune complex formation PMID:23408612
PR:000044767
NS4B (DEN26)
participates_in GO:0039563 suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity PMID:14612562
PR:000044761
NS2B (DEN2N)
capable_of GO:0008236 serine-type peptidase activity PMID:10744671
participates_in GO:1900005 positive regulation of serine-type endopeptidase activity PMID:10744671
PR:000044760
NS2A (DEN26)
participates_in GO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044763
NS4A (DEN2N)
located_in GO:0019034 viral replication complex PMID:17276984
participates_in GO:0019079 viral genome replication PMID:17276984
PR:000044762
NS3 (DEN2N)
capable_of GO:0008236 serine-type peptidase activity PMID:10744671
capable_of GO:0017111 nucleoside-triphosphatase activity PMID:10744671
capable_of GO:0003724 RNA helicase activity PMID:10744671
participates_in GO:0019082 viral protein processing PMID:10744671
PR:000044765
2K (DEN2N)
capable_of GO:0043495 protein-membrane adaptor activity PMID:21810535
located_in GO:0031225 anchored component of membrane PMID:21810535
participates_in GO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PMID:17276984
PR:000044764
NS4A (DEN26)
participates_in GO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044770
prM (DEN2N)
Asn-183, MOD:00160 		located_in GO:0019031 viral envelope PMID:8429301
participates_in GO:0046730 induction by virus of host immune response PMID:8429301
PR:000044766
NS4B (DEN2N)
located_in GO:0019034 viral replication complex PMID:21810535
participates_in GO:0019079 viral genome replication PMID:21810535
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0060339 negative regulation of type I interferon-mediated signaling pathway PR:000044760 NS2A (DEN26)

PMID:14612562
PR:000044764 NS4A (DEN26)

PMID:14612562
GO:0019079 viral genome replication PR:000037002 NS1 dimer

PMID:8659120
PR:000044758 NS1 (DEN2N)
Asn-905/Asn-982, MOD:00160
PMID:23408612
PR:000044759 NS2A (DEN2N)

PMID:23408612
PR:000044763 NS4A (DEN2N)

PMID:17276984
PR:000044766 NS4B (DEN2N)

PMID:21810535
PR:000044768 NS5 (DEN2N)

PMID:21810535
GO:0019076 viral release from host cell PR:000044759 NS2A (DEN2N)

PMID:23408612
GO:0039563 suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity PR:000044767 NS4B (DEN26)

PMID:14612562
GO:0016540 protein autoprocessing PR:000036829 NS2B-NS3 complex

PMID:23511634
GO:0019064 fusion of virus membrane with host plasma membrane PR:000036999 E protein dimer

PMID:14963133
GO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PR:000044765 2K (DEN2N)

PMID:17276984
GO:0097281 immune complex formation PR:000037002 NS1 dimer

PMID:8659120
PR:000044758 NS1 (DEN2N)
Asn-905/Asn-982, MOD:00160
PMID:23408612
GO:0042783 evasion of host immune response PR:000044768 NS5 (DEN2N)

PMID:21810535
GO:0001510 RNA methylation PR:000044768 NS5 (DEN2N)

PMID:21810535
GO:1900005 positive regulation of serine-type endopeptidase activity PR:000044761 NS2B (DEN2N)

PMID:10744671
GO:0019082 viral protein processing PR:000036829 NS2B-NS3 complex

PMID:10744671
PR:000036829 NS2B-NS3 complex

PMID:23511634
PR:000044762 NS3 (DEN2N)

PMID:10744671
GO:0019068 virion assembly PR:000044759 NS2A (DEN2N)

PMID:23408612
PR:000044769 prM (DEN26)
Asn-183, MOD:00160
PMID:14963133
GO:0015031 protein transport PR:000044769 prM (DEN26)
Asn-183, MOD:00160
PMID:14963133
GO:0046730 induction by virus of host immune response PR:000044757 M (DEN26)

PMID:14963133
PR:000044770 prM (DEN2N)
Asn-183, MOD:00160
PMID:8429301
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0019034 viral replication complex PR:000037002 NS1 dimer

PMID:8659120
PR:000044758 NS1 (DEN2N)
Asn-905/Asn-982, MOD:00160
PMID:23408612
PR:000044759 NS2A (DEN2N)

PMID:23408612
PR:000044763 NS4A (DEN2N)

PMID:17276984
PR:000044766 NS4B (DEN2N)

PMID:21810535
PR:000044768 NS5 (DEN2N)

PMID:21810535
GO:0031225 anchored component of membrane PR:000044765 2K (DEN2N)

PMID:21810535
GO:0005615 extracellular space PR:000037005 NS1 hexamer, with complex sugar attached

PMID:8659120
GO:0019031 viral envelope PR:000036999 E protein dimer

PMID:14963133
PR:000044757 M (DEN26)

PMID:14963133
PR:000044770 prM (DEN2N)
Asn-183, MOD:00160
PMID:8429301

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