Entry Report [PIR] - PR:000035404

Protein Ontology Report - frog-BUB1/Phos:3

PR:000035404 - http://purl.obolibrary.org/obo/PR_000035404

Protein Forms Annotations

Ontology Information

PRO ID

PR:000035404 Show OBO stanza / PAF

PRO name

mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)

Synonyms

PRO-short-label:	frog-BUB1/Phos:3
PRO-proteoform-std:	UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046
RELATED:	xBUB1 hyperphosphorylated

Definition

A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046. [PMID:15241477, PRO:KER]

Comment

Phosphorylation at Ser-500 is the most critical for checkpoint function. This form is observed during spindle disruption (nocodazole). Kinase=("MAPK"; PR:000000019).

PRO Category

organism-modification

Parent

PR:000035403 mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000035404 frog-BUB1/Phos:3 Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046	capable_of	GO:0004672 protein kinase activity increased relative to PR:000029917 frog-BUB1/PhosRes-	PMID:15241477
	participates_in	GO:0034501 protein localization to kinetochore	PMID:15241477
	participates_in	GO:0034501 protein localization to kinetochore	PMID:15241477
	participates_in	GO:0031577 spindle checkpoint signaling	PMID:15241477
	participates_in	GO:0034501 protein localization to kinetochore	PMID:15241477

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0031577 spindle checkpoint signaling	PR:000035404 frog-BUB1/Phos:3 Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046	PMID:15241477
GO:0034501 protein localization to kinetochore	PR:000035404 frog-BUB1/Phos:3 Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046	PMID:15241477
	PR:000035404 frog-BUB1/Phos:3 Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046	PMID:15241477
	PR:000035404 frog-BUB1/Phos:3 Thr-493/Thr-650, MOD:00047\|Ser-500/Ser-634, MOD:00046	PMID:15241477

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