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Protein Ontology Report - SPTLC1

PR:000015596 - http://purl.obolibrary.org/obo/PR_000015596
Ontology Information
PRO ID PR:000015596 Show OBO stanza / PAF
PRO name serine palmitoyltransferase 1
Synonyms
PRO-short-label: SPTLC1
EXACT: LCB 1; SPT 1; SPT1; long chain base biosynthesis protein 1; serine-palmitoyl-CoA transferase 1
Gene-based: LCB1
Definition A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000026126 eukaryotic serine palmitoyltransferase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 8
sequence 1 organism-sequence 3
modification 0 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

SPTLC1 forms found in complexes
SPTLC1 Component Complexes
PR:O15269 hSPTLC1 PR:000026155 serine palmitoyltransferase complex A (human)
PR:O15269 hSPTLC1 PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:O15269 hSPTLC1 PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:O15269 hSPTLC1 PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:O15269 hSPTLC1 PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:O15269 hSPTLC1 PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:O35704 mSPTLC1 PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000026144
serine palmitoyltransferase complex core 1 (human)
capable_of GO:0004758 serine C-palmitoyltransferase activity PMID:19416851
PR:O35704-1
mSPTLC1/iso:1
capable_of GO:0005515 protein binding with PR:P41233 mABCA1 PMID:18484747
capable_of NOT GO:0004758 serine C-palmitoyltransferase activity PMID:9363775
PR:O35704
mSPTLC1
participates_in GO:0046511 sphinganine biosynthetic process PMID:19416652
participates_in GO:0046512 sphingosine biosynthetic process PMID:16216550
participates_in GO:0046513 ceramide biosynthetic process PMID:16216550
participates_in GO:0006686 sphingomyelin biosynthetic process PMID:16216550
PR:000026154
serine palmitoyltransferase complex 6 (human)
capable_of GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851
PR:000026153
serine palmitoyltransferase complex 5 (human)
capable_of GO:0004758 serine C-palmitoyltransferase activity increased relative to PR:000026144 serine palmitoyltransferase complex core 1 (human) PMID:19416851
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0046512 sphingosine biosynthetic process PR:O35704 mSPTLC1

PMID:16216550
GO:0046511 sphinganine biosynthetic process PR:O35704 mSPTLC1

PMID:19416652
GO:0046513 ceramide biosynthetic process PR:O35704 mSPTLC1

PMID:16216550
GO:0006686 sphingomyelin biosynthetic process PR:O35704 mSPTLC1

PMID:16216550

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