Entry Report [PIR] - PR:000004517

Protein Ontology Report - AURKB

PR:000004517 - http://purl.obolibrary.org/obo/PR_000004517

Protein Forms Annotations

Ontology Information

PRO ID

PR:000004517 Show OBO stanza / PAF

PRO name

aurora kinase B

Synonyms

PRO-short-label:	AURKB
EXACT:	AIM-1; ARK-2; aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B
Gene-based:	AIK2; AIM1; AIRK2; ARK2; STK12
RELATED:	STK-1; Stk1; Stk5

Definition

An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof. [PRO:DNx]

PRO Category

gene

Parent

PR:000035365 aurora kinase

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	8
sequence	0	organism-sequence	5
modification	3	organism-modification	4
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	IUPHARobj:1937

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000035661 hAURKB/PhosRes-	capable_of	GO:0005515 protein binding with PR:Q9NQS7 hINCENP	PMID:22024163
PR:000035661 hAURKB/PhosRes-	located_in	GO:0000776 kinetochore	PMID:22024163
PR:Q96GD4 hAURKB	capable_of	GO:0005515 protein binding with PR:Q12834 hCDC20	BioGRID:BG-684898
	capable_of	GO:0005515 protein binding with PR:O15392 hBIRC5	BioGRID:BG-571501, IntAct:EBI-979359, MINT:MINT-4509558
	capable_of	GO:0005515 protein binding with PR:P06493 hCDK1	IntAct:EBI-1397755
	capable_of	GO:0005515 protein binding with PR:Q9NQS7 hINCENP	BioGRID:BG-251075, IntAct:EBI-1555366, MINT:MINT-77928
	capable_of	GO:0005515 protein binding with PR:Q13043 hSTK4	PMID:20171103
	capable_of	GO:0005515 protein binding with PR:Q53HL2 hCDCA8	BioGRID:BG-251030
	capable_of	GO:0005515 protein binding with PR:O60566 hBUB1B	BioGRID:BG-717913
	capable_of	GO:0005515 protein binding with PR:P68431 hH3.1	BioGRID:BG-530650
	capable_of	GO:0004672 protein kinase activity	PMID:12719470
	capable_of	GO:0005515 protein binding with PR:Q71DI3 hH3.2	BioGRID:BG-725715
	capable_of	GO:0005515 protein binding with PR:Q15208 hSTK38	PMID:20171103
	located_in	GO:0000779 condensed chromosome, centromeric region	PMID:12719470, PMID:15917996
	located_in	GO:0051233 spindle midzone	PMID:15917996
	located_in	GO:0030496 midbody	PMID:15917996
	located_in	GO:0000939 inner kinetochore	PMID:15592459
	located_in	GO:0000776 kinetochore	PMID:20624902
	participates_in	GO:0008608 attachment of spindle microtubules to kinetochore	PMID:12719470, PMID:15592459
	participates_in	GO:0051310 metaphase plate congression	PMID:12719470, PMID:22732840
	participates_in	GO:0140014 mitotic nuclear division	PMID:12719470
	participates_in	NOT GO:0051306 mitotic sister chromatid separation	PMID:12719470
	participates_in	GO:0007059 chromosome segregation	PMID:12719470
	participates_in	GO:0034501 protein localization to kinetochore	PMID:12719470, PMID:17617734, PMID:22732840
	participates_in	GO:0031577 spindle checkpoint signaling	PMID:12719470
	participates_in	GO:0071459 protein localization to chromosome, centromeric region	PMID:12719470, PMID:21658950
PR:000035663 hAURKB/Phos:1 Ser-331, MOD:00046	capable_of	GO:0005515 protein binding with PR:Q9NQS7 hINCENP	PMID:22024163
	capable_of	GO:0004672 protein kinase activity increased relative to PR:000035661 hAURKB/PhosRes-	PMID:17276342, PMID:22024163
	located_in	GO:0000776 kinetochore	PMID:22024163
	participates_in	GO:0051310 metaphase plate congression increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
	participates_in	GO:0031577 spindle checkpoint signaling increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
	participates_in	GO:0007059 chromosome segregation increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0051310 metaphase plate congression	PR:000035663 hAURKB/Phos:1 Ser-331, MOD:00046 increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
GO:0051310 metaphase plate congression	PR:Q96GD4 hAURKB	PMID:12719470, PMID:22732840
NOT GO:0051306 mitotic sister chromatid separation	PR:Q96GD4 hAURKB	PMID:12719470
GO:0007059 chromosome segregation	PR:000035663 hAURKB/Phos:1 Ser-331, MOD:00046 increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
GO:0007059 chromosome segregation	PR:Q96GD4 hAURKB	PMID:12719470
GO:0008608 attachment of spindle microtubules to kinetochore	PR:Q96GD4 hAURKB	PMID:12719470, PMID:15592459
GO:0034501 protein localization to kinetochore	PR:Q96GD4 hAURKB	PMID:12719470, PMID:17617734, PMID:22732840
GO:0031577 spindle checkpoint signaling	PR:000035663 hAURKB/Phos:1 Ser-331, MOD:00046 increased relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
GO:0031577 spindle checkpoint signaling	PR:Q96GD4 hAURKB	PMID:12719470
GO:0071459 protein localization to chromosome, centromeric region	PR:Q96GD4 hAURKB	PMID:12719470, PMID:21658950
GO:0140014 mitotic nuclear division	PR:Q96GD4 hAURKB	PMID:12719470

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0000779 condensed chromosome, centromeric region	PR:Q96GD4 hAURKB	PMID:12719470, PMID:15917996
GO:0051233 spindle midzone	PR:Q96GD4 hAURKB	PMID:15917996
GO:0000939 inner kinetochore	PR:Q96GD4 hAURKB	PMID:15592459
GO:0000776 kinetochore	PR:000035661 hAURKB/PhosRes-	PMID:22024163
	PR:000035663 hAURKB/Phos:1 Ser-331, MOD:00046	PMID:22024163
	PR:Q96GD4 hAURKB	PMID:20624902
GO:0030496 midbody	PR:Q96GD4 hAURKB	PMID:15917996

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