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Protein Ontology Report - caspase-8-like protease

PR:000002197 - http://purl.obolibrary.org/obo/PR_000002197
Ontology Information
PRO ID PR:000002197 Show OBO stanza / PAF
PRO name caspase-8-like protease
Definition A protein that is a translation product of the human CASP8, CASP10, or CFLAR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The core domain architecture consists of two consecutive copies of the Death effector domain (DED) domain (Pfam:PF01335) in an amino-terminal propeptide followed by Peptidase_C14 domain (Pfam:PF00656). Encoded as zymogens, the activated proteins are cysteine proteases typically involved in apoptosis. [PRO:DAN, PRO:WCB]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000002197
caspase-8-like protease
has_part Pfam:PF00656 Caspase domain
has_part Pfam:PF01335 Death effector domain

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