Entry Report [PIR] - PR:000001749

Protein Ontology Report - TICAM1

PR:000001749 - http://purl.obolibrary.org/obo/PR_000001749

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000001749 Show OBO stanza / PAF

PRO name

TIR domain-containing adapter molecule 1

Synonyms

PRO-short-label:	TICAM1
EXACT:	TICAM-1; TIR domain-containing adapter protein inducing IFN-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; proline-rich, vinculin and TIR domain-containing protein B; putative NF-kappa-B-activating protein 502H
Gene-based:	PRVTIRB; TRIF

Definition

A protein that is a translation product of the human TICAM1 gene or a 1:1 ortholog thereof. [PRO:CNA]

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	3
sequence	0	organism-sequence	0
modification	1	organism-modification	0
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	PIRSF:PIRSF037744

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

TICAM1 forms found in complexes

TICAM1 Component	Complexes
PR:A0FKC7 chick-TICAM1	PR:000037462 ticam1:viral dsRNA:TLR3 complex (chicken)
PR:Q80UF7 mTICAM1	PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036090 tbk1:tank:ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036093 tbk1:K63-poly-Ub-tank:Ikke:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036095 K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036097 tbk1:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036099 ikke:K63-poly-Ub-tank:traf3:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q80UF7 mTICAM1	PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:Q8IUC6 hTICAM1	PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037330 SARM:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8IUC6 hTICAM1	PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:Q8IUC6 hTICAM1	PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037332 rip3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037334 rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037344 traf6:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)
PR:Q8IUC6 hTICAM1	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_25867
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_124855
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_7861
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
	participates_in	GO:0034142 toll-like receptor 4 signaling pathway	Reactome:REACT_6809
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_25755
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004197 cysteine-type endopeptidase activity	Reactome:REACT_151344
	located_in	GO:0010008 endosome membrane	Reactome:REACT_151344
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	PMID:16306937
	participates_in	GO:0034142 toll-like receptor 4 signaling pathway	PMID:16306937
PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)	located_in	GO:0010008 endosome membrane	PMID:18222170
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	PMID:18222170
	participates_in	GO:0034142 toll-like receptor 4 signaling pathway	PMID:18222170
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_151758
	participates_in	GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_151758
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_26959
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_25948
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037344 traf6:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_26036
	located_in	GO:0010008 endosome membrane	Reactome:REACT_26036
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_25948
	participates_in	GO:0034142 toll-like receptor 4 signaling pathway	Reactome:REACT_6809
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004842 ubiquitin-protein transferase activity	Reactome:REACT_124037
	located_in	GO:0010008 endosome membrane	Reactome:REACT_124037
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_124037
PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	PMID:14530355
PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_26959
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	PMID:12539043
PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	PMID:12539043
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_152149
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_26016
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:A0FKC7 chick-TICAM1	located_in	GO:0005829 cytosol	Reactome:REACT_26995
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_151344
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_26039
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	capable_of	GO:0004674 protein serine/threonine kinase activity	Reactome:REACT_27000
	located_in	GO:0010008 endosome membrane	Reactome:REACT_27000
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809
PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	PMID:12133833, PMID:17327220
PR:000037310 traf3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	PMID:16306936, PMID:16306937
PR:000037330 SARM:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037332 rip3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
PR:000037334 rip1:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
	participates_in	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	participates_in	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway	PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)	PMID:18222170
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)	PMID:16306937
	PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)	PMID:14530355
	PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_124037
	PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)	Reactome:REACT_6809
	PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	Reactome:REACT_6809
	PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	Reactome:REACT_6809
	PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)	Reactome:REACT_6783
	PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)	PMID:12539043
	PR:000037310 traf3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037332 rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037334 rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037344 traf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
GO:0034142 toll-like receptor 4 signaling pathway	PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)	PMID:18222170
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_6809
	PR:000028683 traf3:ticam1:ticam2:activated TLR4 complex (mouse)	PMID:16306937
GO:0034138 toll-like receptor 3 signaling pathway	PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)	Reactome:REACT_6783
	PR:000037308 ticam1:viral dsRNA:TLR3 complex (mouse)	PMID:12539043
	PR:000037310 traf3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)	PMID:16306936, PMID:16306937
	PR:000037313 tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)	PMID:12133833, PMID:17327220
	PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037330 SARM:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037332 rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037334 rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037344 traf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway	PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_151758
	PR:000037330 SARM:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005829 cytosol	PR:A0FKC7 chick-TICAM1	Reactome:REACT_26995
GO:0010008 endosome membrane	PR:000027207 ticam1:ticam2:activated TLR4 complex (mouse)	PMID:18222170
	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_7861
	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_25948
	PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_25867
	PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_26036
	PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_26039
	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_124037
	PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_25948
	PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_151758
	PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_27000
	PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_124855
	PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_25755
	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_26016
	PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_152149
	PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_151344
	PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)	Reactome:REACT_151344
	PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	Reactome:REACT_26959
	PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)	Reactome:REACT_26959
	PR:000037307 ticam1:viral dsRNA:TLR3 complex (human)	Reactome:REACT_6783
	PR:000037310 traf3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037330 SARM:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037332 rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037334 rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037344 traf6:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783
	PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

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