[Term]
id: PR:000001749
name: TIR domain-containing adapter molecule 1
def: "A protein that is a translation product of the human TICAM1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TRIF" RELATED Gene-based []
synonym: "TICAM1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRVTIRB" RELATED Gene-based []
synonym: "TICAM-1" EXACT []
synonym: "putative NF-kappa-B-activating protein 502H" EXACT []
synonym: "TIR domain-containing adapter protein inducing IFN-beta" EXACT []
synonym: "proline-rich, vinculin and TIR domain-containing protein B" EXACT []
synonym: "Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta" EXACT []
xref: PIRSF:PIRSF037744
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8IUC6
name: TIR domain-containing adapter molecule 1 (human)
def: "A TIR domain-containing adapter molecule 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "TRIF" RELATED Gene-based [UniProtKB:Q8IUC6]
synonym: "TICAM1" RELATED Gene-based [UniProtKB:Q8IUC6]
synonym: "PRVTIRB" RELATED Gene-based [UniProtKB:Q8IUC6]
synonym: "hTICAM1" EXACT PRO-short-label [PRO:DNx]
synonym: "MyD88-3 (human)" EXACT [UniProtKB:Q8IUC6]
synonym: "TICAM-1 (human)" EXACT [UniProtKB:Q8IUC6]
synonym: "putative NF-kappa-B-activating protein 502H (human)" EXACT [UniProtKB:Q8IUC6]
synonym: "TIR domain-containing adapter protein inducing IFN-beta (human)" EXACT [UniProtKB:Q8IUC6]
synonym: "proline-rich, vinculin and TIR domain-containing protein B (human)" EXACT [UniProtKB:Q8IUC6]
synonym: "Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta (human)" EXACT [UniProtKB:Q8IUC6]
xref: UniProtKB:Q8IUC6
xref: Reactome:R-HSA-166170 "PR:Q8IUC6 located_in GO:0005829"
xref: Reactome:R-HSA-450316 "PR:Q8IUC6 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001749 ! TIR domain-containing adapter molecule 1
relationship: has_gene_template HGNC:18348 ! TICAM1 (human)

[Term]
id: PR:Q80UF7
name: TIR domain-containing adapter molecule 1 (mouse)
def: "A TIR domain-containing adapter molecule 1 that is encoded in the genome of mouse." [OMA:Q80UF7, PRO:CNA]
comment: Category=organism-gene.
synonym: "Trif" RELATED Gene-based [UniProtKB:Q80UF7]
synonym: "Ticam1" RELATED Gene-based [UniProtKB:Q80UF7]
synonym: "mTICAM1" EXACT PRO-short-label [PRO:DNx]
synonym: "TICAM-1 (mouse)" EXACT [UniProtKB:Q80UF7]
synonym: "TIR domain-containing adapter protein inducing IFN-beta (mouse)" EXACT [UniProtKB:Q80UF7]
synonym: "Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta (mouse)" EXACT [UniProtKB:Q80UF7]
xref: UniProtKB:Q80UF7
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001749 ! TIR domain-containing adapter molecule 1
relationship: has_gene_template MGI:2147032 ! Ticam1 (mouse)

[Term]
id: PR:A0FKC7
name: Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta (chicken)
def: "A TIR domain-containing adapter molecule 1 that is encoded in the genome of chicken." [PMID:17676477, PRO:CNA, Reactome:R-GGA-433866]
comment: Category=organism-gene.
synonym: "chick-TICAM1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:A0FKC7
xref: Reactome:R-GGA-433866 "PR:A0FKC7 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001749 ! TIR domain-containing adapter molecule 1
relationship: has_gene_template CGNC:59240 ! TICAM1 (chicken)

[Term]
id: PR:000028676
name: TIR domain-containing adapter molecule 1 phosphorylated form
def: "A TIR domain-containing adapter molecule 1 that includes at least one phosphorylated residue." [PMID:14530355, PRO:CNA]
comment: Category=modification.
synonym: "TICAM1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000001749 ! TIR domain-containing adapter molecule 1