| PRO ID |
PR:000001719
Show OBO stanza
/ PAF
|
| PRO name |
transient receptor potential cation channel TRPM8 |
| Synonyms |
| PRO-short-label: |
TRPM8 |
| EXACT: |
LTrpC-6; LTrpC6; Trp-p8; long transient receptor potential channel 6; transient receptor potential p8 |
| Gene-based: |
LTRPC6; TRPP8 |
|
| Definition |
A transient receptor potential channel protein that is a translation product of the human TRPM8 gene or a 1:1 ortholog thereof. TRPM8 is a member of the subfamily M of the transient receptor potential cation channels (TRPs). In common with other TRPs, these proteins have amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity.TRPM8 forms a nonselective cation channel that is activated by cold and by menthol and other substances that produce the sensation of coolness. These channels exhibit voltage-dependance and regulation by phosphatidylinositol-4,5-bisphosphate (PIP2).
[PMID:15852009, PRO:CNA]
|
| PRO Category |
gene |
| Parent |
PR:000044657 transient receptor potential channel protein |
| Terms by PRO Category |
Retrieve All terms OBO Stanza
/ PAF
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms |
|
gene
|
1 |
organism-gene
|
3 |
|
sequence
|
3 |
organism-sequence
|
5 |
|
modification
|
2 |
organism-modification
|
1 |
|
union
|
0 |
|
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