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Protein Ontology Report - IL17A

PR:000001138 - http://purl.obolibrary.org/obo/PR_000001138
Ontology Information
PRO ID PR:000001138 Show OBO stanza / PAF
PRO name interleukin-17A
Synonyms
PRO-short-label: IL17A
EXACT: CTLA-8; IL-17A; cytotoxic T-lymphocyte-associated antigen 8
Gene-based: CTLA8; IL17
RELATED: IL-17
Definition An interleukin-17 that is a translation product of the human IL17A gene or a 1:1 ortholog thereof. The active product is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. [PRO:CNA, Wikipedia:IL17A]
PRO Category gene
Parent PR:000001092 interleukin-17
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 0
modification 2 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IL17A forms found in complexes
IL17A Component Complexes
PR:000036602 hIL17A/SigPep- PR:000044528 interleukin 17F/17A heterodimer (human)
PR:000036602 hIL17A/SigPep- PR:000044530 interleukin 17A homodimer (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036602
hIL17A/SigPep-
capable_of GO:0005125 cytokine activity PMID:7499828
capable_of GO:0042803 protein homodimerization activity PMID:15055556
located_in GO:0005615 extracellular space PMID:15340161, PMID:7499828
PR:000001138
IL17A
has_part Pfam:PF06083 Interleukin-17
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005615 extracellular space PR:000036602 hIL17A/SigPep-

PMID:15340161, PMID:7499828

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