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Protein Ontology Report - EZR

PR:000001031 - http://purl.obolibrary.org/obo/PR_000001031
Ontology Information
PRO ID PR:000001031 Show OBO stanza / PAF
PRO name ezrin
Synonyms
PRO-short-label: EZR
BROAD: p81
EXACT: cytovillin; villin-2
Gene-based: VIL2
Definition An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000001030 erm protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 8
modification 9 organism-modification 9
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036589
hEZR/iso:1/Phos:2
Ser-66, MOD:00046 		capable_of GO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod PMID:16438931
PR:000036590
hEZR/iso:1/Phos:3
Tyr-191, MOD:00048 		capable_of GO:0005515 protein binding with PR:P00523-1 chick-SRC/iso:1 PMID:15647376
PR:000036625
hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047 		capable_of GO:0003779 actin binding PMID:18852256
located_in GO:0005886 plasma membrane PMID:18852256
located_in GO:0002102 podosome PMID:18852256
PR:000001032
EZR/iso:1
has_part Pfam:PF00373 FERM central domain
PR:000036592
hEZR/iso:1/Phos:5
Thr-567, MOD:00047 		capable_of GO:0005515 protein binding with PR:P43403 hZAP70 PMID:18025306
located_in GO:0001772 immunological synapse PMID:18025306
located_in GO:0045177 apical part of cell PMID:16144865
participates_in GO:0051279 regulation of release of sequestered calcium ion into cytosol PMID:18025306
participates_in GO:0001771 immunological synapse formation PMID:18025306
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0051279 regulation of release of sequestered calcium ion into cytosol PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:18025306
GO:0001771 immunological synapse formation PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:18025306
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0002102 podosome PR:000036625 hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047
PMID:18852256
GO:0045177 apical part of cell PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:16144865
GO:0005886 plasma membrane PR:000036625 hEZR/iso:1/Phos:6
Tyr-354, MOD:00048|Thr-567, MOD:00047
PMID:18852256
GO:0001772 immunological synapse PR:000036592 hEZR/iso:1/Phos:5
Thr-567, MOD:00047
PMID:18025306

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