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Protein Ontology Report - KCNQ2/iso:6

PR:000000903 - http://purl.obolibrary.org/obo/PR_000000903
Ontology Information
PRO ID PR:000000903 Show OBO stanza
PRO name voltage-gated potassium channel subunit KCNQ2 isoform 6
Synonyms
PRO-short-label: KCNQ2/iso:6
RELATED: HNSPC
Definition A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-6 or a 1:1 ortholog thereof. [PMID:9039501, PRO:CNA, PRO:DAN]
Comment Note: Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation.
PRO Category sequence
Parent PR:000000729 voltage-gated potassium channel subunit KCNQ2
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Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

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