[Term]
id: PR:000000903
name: voltage-gated potassium channel subunit KCNQ2 isoform 6
def: "A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-6 or a 1:1 ortholog thereof." [PMID:9039501, PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation.
synonym: "HNSPC" RELATED []
synonym: "KCNQ2/iso:6" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000729 ! voltage-gated potassium channel subunit KCNQ2