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Protein Ontology Report - HCN4

PR:000000708 - http://purl.obolibrary.org/obo/PR_000000708
Ontology Information
PRO ID PR:000000708 Show OBO stanza / PAF
PRO name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms
PRO-short-label: HCN4
EXACT: BCNG-3; brain cyclic nucleotide-gated channel 3
Gene-based: Bcng3
Definition A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN4 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 4
modification 2 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q9Y3Q4-1
hHCN4/iso:1
capable_of GO:0005261 cation channel activity PMID:10228147
participates_in GO:0006812 cation transport PMID:10228147
participates_in GO:0006936 muscle contraction PMID:10228147
PR:000000759
hHCN4/var:D553N
Asp-553, CHEBI:50347 		associated_with_disease_progression DOID:13884 sick sinus syndrome PMID:15123648
located_in NOT GO:0005886 plasma membrane PMID:15123648
PR:Q9TV66-1
rabbit-HCN4/iso:r1
located_in GO:0005886 plasma membrane PMID:15123648
PR:000000760
hHCN4/var:S672R
Ser-672, CHEBI:29952 		associated_with_disease_progression DOID:13884 sick sinus syndrome PMID:16407510
capable_of GO:0005222 intracellular cAMP-activated cation channel activity PMID:16407510
capable_of GO:0022843 voltage-gated cation channel activity PMID:16407510
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006812 cation transport PR:Q9Y3Q4-1 hHCN4/iso:1

PMID:10228147
GO:0006936 muscle contraction PR:Q9Y3Q4-1 hHCN4/iso:1

PMID:10228147
Cellular Location GO Term Protein Forms & Complexes Evidence
NOT GO:0005886 plasma membrane PR:000000759 hHCN4/var:D553N
Asp-553, CHEBI:50347
PMID:15123648
GO:0005886 plasma membrane PR:Q9TV66-1 rabbit-HCN4/iso:r1

PMID:15123648

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