[Term]
id: PR:000000758
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y3Q4-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "HCN4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

[Term]
id: PR:000000759
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Asn residue at the position equivalent to Asp-553 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347." [PMID:15123648, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hHCN4/var:D553N" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_026534
is_a: PR:Q9Y3Q4 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000002604
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 unmodified form
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "HCN4/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000758 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:O70507
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of mouse." [OMA:O70507, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hcn4" RELATED Gene-based [UniProtKB:O70507]
synonym: "Bcng3" RELATED Gene-based [UniProtKB:O70507]
synonym: "mHCN4" EXACT PRO-short-label [PRO:DNx]
synonym: "BCNG-3 (mouse)" EXACT [UniProtKB:O70507]
synonym: "brain cyclic nucleotide-gated channel 3 (mouse)" EXACT [UniProtKB:O70507]
xref: UniProtKB:O70507
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
relationship: has_gene_template MGI:1298209 ! Hcn4 (mouse)

[Term]
id: PR:000000760
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Arg residue at the position equivalent to Ser-672 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952." [PMID:16407510, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This residue is located in the CNBD.
synonym: "hHCN4/var:S672R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_026535
is_a: PR:Q9Y3Q4 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000029935
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that has been phosphorylated at the position equivalent to Ser-921 of the amino acid sequence represented by UniProtKB:O70507. Example: UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
comment: Category=modification. Note: Large-scale experiment.
synonym: "HCN4/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q9TV66-1
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9TV66-1." [PRO:DAN]
comment: Category=organism-sequence. Note: This appears to be a different isoform than 'isoform 1' of human.
synonym: "rabbit-HCN4/iso:r1" EXACT PRO-short-label [PRO:DAN]
xref: UniProtKB:Q9TV66-1
is_a: PR:Q9TV66 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
relationship: only_in_taxon NCBITaxon:9986 ! Oryctolagus cuniculus

[Term]
id: PR:000029936
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 in mouse. UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
comment: Category=organism-modification. Note: Large-scale experiment.
synonym: "mHCN4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O70507, Ser-921, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000029935 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q9TV66
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rabbit." [PRO:DAN]
comment: Category=organism-gene.
synonym: "HAC4" RELATED Gene-based [UniProtKB:Q9TV66]
synonym: "HCN4" RELATED Gene-based [UniProtKB:Q9TV66]
synonym: "rabbit-HCN4" EXACT PRO-short-label [PRO:DAN]
synonym: "HAC-4 (rabbit)" EXACT [UniProtKB:Q9TV66]
synonym: "hyperpolarization-activated cation channel 4 (rabbit)" EXACT [UniProtKB:Q9TV66]
xref: UniProtKB:Q9TV66
intersection_of: only_in_taxon NCBITaxon:9986 ! Oryctolagus cuniculus
intersection_of: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
relationship: has_gene_template NCBIGene:100009452 ! HCN4 (rabbit)

[Term]
id: PR:Q9JKA7
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rat)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rat." [OMA:Q9JKA7, PANTHER:PTHR10217:SF375, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hcn4" RELATED Gene-based [UniProtKB:Q9JKA7]
synonym: "rHCN4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9JKA7
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
relationship: has_gene_template RGD:71065 ! Hcn4 (rat)

[Term]
id: PR:Q9Y3Q4
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y3Q4]
comment: Category=organism-gene.
synonym: "HCN4" RELATED Gene-based [UniProtKB:Q9Y3Q4]
synonym: "hHCN4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y3Q4
xref: Reactome:R-HSA-977498 "PR:Q9Y3Q4 located_in GO:0005886"
xref: DTO:01100147
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000708 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
relationship: has_gene_template HGNC:16882 ! HCN4 (human)

[Term]
id: PR:Q9Y3Q4-1
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hHCN4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y3Q4-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000758 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1

[Term]
id: PR:000000708
name: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
def: "A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN4 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "HCN4" EXACT PRO-short-label [PRO:DNx]
synonym: "Bcng3" RELATED Gene-based []
synonym: "BCNG-3" EXACT []
synonym: "brain cyclic nucleotide-gated channel 3" EXACT []
xref: IUPHARobj:403
xref: PIRSF:PIRSF500963
is_a: PR:000000676 ! potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein