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Protein Ontology Report - FASLG

PR:000000095 - http://purl.obolibrary.org/obo/PR_000000095
Ontology Information
PRO ID PR:000000095 Show OBO stanza / PAF
PRO name tumor necrosis factor ligand superfamily member 6
Synonyms
PRO-short-label: FASLG
EXACT: APTL; CD178; CD95 ligand; CD95-L; apoptosis antigen ligand; fas antigen ligand; fas ligand; fas ligand, TNF-like
Gene-based: APT1LG1; CD95L; FASL; TNFSF6; gld
Definition A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000033 tumor necrosis factor, TNF-like
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 3 organism-sequence 6
modification 4 organism-modification 2
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000095
FASLG
participates_in GO:0007267 cell-cell signaling PANTHER:PTHR11471:SF7
PR:000036458
hFASLG/iso:FasL/NGlyco:1
Asn-184/Asn-250/Asn-260, MOD:00160 		capable_of GO:0005102 signaling receptor binding PMID:9405425
participates_in GO:0097190 apoptotic signaling pathway PMID:9405425
PR:000036459
hFASLG/iso:FasL/Clv:soluble
capable_of GO:0042802 identical protein binding PMID:7536672, PMID:9228058, PMID:9405425
capable_of GO:0005102 signaling receptor binding PMID:9405425
located_in GO:0005615 extracellular space PMID:7536672
participates_in GO:0043066 negative regulation of apoptotic process PMID:9396774
PR:P41047-1
mFASLG/iso:FasL
located_in GO:0009986 cell surface PMID:16973387
located_in GO:0005887 integral component of plasma membrane PMID:16973387
participates_in GO:0043066 negative regulation of apoptotic process MGI:76989, PMID:7595210
participates_in GO:0006915 apoptotic process PMID:16365167
participates_in GO:0097190 apoptotic signaling pathway PMID:15039234
PR:P41047-2
mFASLG/iso:FasLS
located_in GO:0005615 extracellular space PMID:10552956
participates_in GO:0043066 negative regulation of apoptotic process PMID:10552956
PR:000036782
hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006 		capable_of GO:0005102 signaling receptor binding with PR:P25445 hFAS PMID:9405425
capable_of GO:0042802 identical protein binding with PR:000000278 FASLG/iso:FasL/var:F273L PMID:9405425
located_in GO:0009986 cell surface PMID:9405425
PR:000036783
mFASLG/iso:FasL/var:F273L
Phe-273, CHEBI:30006 		associated_with_disease_progression DOID:6688 autoimmune lymphoproliferative syndrome PMID:7495745
located_in GO:0005887 integral component of plasma membrane PMID:7495745
PR:P48023-1
hFASLG/iso:FasL
participates_in GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling PMID:12761501
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:9396774
PR:P41047-1 mFASLG/iso:FasL

MGI:76989, PMID:7595210
PR:P41047-2 mFASLG/iso:FasLS

PMID:10552956
GO:0006915 apoptotic process PR:P41047-1 mFASLG/iso:FasL

PMID:16365167
GO:0007267 cell-cell signaling PR:000000095 FASLG

PANTHER:PTHR11471:SF7
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling PR:P48023-1 hFASLG/iso:FasL

PMID:12761501
GO:0097190 apoptotic signaling pathway PR:000036458 hFASLG/iso:FasL/NGlyco:1
Asn-184/Asn-250/Asn-260, MOD:00160
PMID:9405425
PR:P41047-1 mFASLG/iso:FasL

PMID:15039234
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:000036782 hFASLG/iso:FasL/var:F273L
Phe-275, CHEBI:30006
PMID:9405425
PR:P41047-1 mFASLG/iso:FasL

PMID:16973387
GO:0005887 integral component of plasma membrane PR:000036783 mFASLG/iso:FasL/var:F273L
Phe-273, CHEBI:30006
PMID:7495745
PR:P41047-1 mFASLG/iso:FasL

PMID:16973387
GO:0005615 extracellular space PR:000036459 hFASLG/iso:FasL/Clv:soluble

PMID:7536672
PR:P41047-2 mFASLG/iso:FasLS

PMID:10552956

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