[Term] id: PR:000000095 name: tumor necrosis factor ligand superfamily member 6 def: "A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "gld" RELATED Gene-based [] synonym: "APTL" EXACT [] synonym: "FASL" RELATED Gene-based [] synonym: "CD178" EXACT [] synonym: "CD95L" RELATED Gene-based [] synonym: "FASLG" EXACT PRO-short-label [PRO:DNx] synonym: "CD95-L" EXACT [] synonym: "TNFSF6" RELATED Gene-based [] synonym: "APT1LG1" RELATED Gene-based [] synonym: "fas ligand" EXACT [] synonym: "CD95 ligand" EXACT [] synonym: "fas antigen ligand" EXACT [] synonym: "fas ligand, TNF-like" EXACT [] synonym: "apoptosis antigen ligand" EXACT [] xref: PANTHER:PTHR11471:SF7 is_a: PR:000000033 ! tumor necrosis factor, TNF-like [Term] id: PR:000000432 name: tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL that includes at least one glycosylated residue." [PRO:CNA] comment: Category=modification. synonym: "FASLG/iso:FasL/GlycoRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00693 ! glycosylated residue intersection_of: PR:000000276 ! tumor necrosis factor ligand superfamily member 6 isoform FasL [Term] id: PR:P48023-1 name: tumor necrosis factor ligand superfamily member 6 isoform FasL (human) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hFASLG/iso:FasL" EXACT PRO-short-label [PRO:DNx] synonym: "FASLG isoform 1 (human)" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform 1 (human)" EXACT [PRO:DNx] xref: UniProtKB:P48023-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000276 ! tumor necrosis factor ligand superfamily member 6 isoform FasL [Term] id: PR:P48023-2 name: tumor necrosis factor ligand superfamily member 6 isoform h2 (human) def: "A tumor necrosis factor ligand superfamily member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-2." [PRO:DNx, UniProtKB:P48023] comment: Category=organism-sequence. synonym: "hFASLG/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P48023-2 is_a: PR:P48023 ! tumor necrosis factor ligand superfamily member 6 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P48023 name: tumor necrosis factor ligand superfamily member 6 (human) def: "A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023] comment: Category=organism-gene. synonym: "FASL" RELATED Gene-based [UniProtKB:P48023] synonym: "CD95L" RELATED Gene-based [UniProtKB:P48023] synonym: "FASLG" RELATED Gene-based [UniProtKB:P48023] synonym: "TNFSF6" RELATED Gene-based [UniProtKB:P48023] synonym: "hFASLG" EXACT PRO-short-label [PRO:DNx] synonym: "APT1LG1" RELATED Gene-based [UniProtKB:P48023] synonym: "APTL (human)" EXACT [UniProtKB:P48023] synonym: "CD178 (human)" EXACT [UniProtKB:P48023] synonym: "CD95-L (human)" EXACT [UniProtKB:P48023] synonym: "Fas ligand (human)" EXACT [UniProtKB:P48023] synonym: "CD95 ligand (human)" EXACT [UniProtKB:P48023] synonym: "Fas antigen ligand (human)" EXACT [UniProtKB:P48023] synonym: "apoptosis antigen ligand (human)" EXACT [UniProtKB:P48023] xref: Reactome:R-HSA-66212 "PR:P48023 located_in GO:0005576" xref: UniProtKB:P48023 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 relationship: has_gene_template HGNC:11936 ! FASLG (human) [Term] id: PR:000018277 name: tumor necrosis factor ligand superfamily member 6 proteolytic cleavage product def: "A tumor necrosis factor ligand superfamily member 6 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "FASLG/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 [Term] id: PR:P36940 name: tumor necrosis factor ligand superfamily member 6 (rat) def: "A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of rat." [OMA:P36940, PANTHER:PTHR11471:SF7, PRO:DNx] comment: Category=organism-gene. synonym: "Fasl" RELATED Gene-based [UniProtKB:P36940] synonym: "Cd95l" RELATED Gene-based [UniProtKB:P36940] synonym: "Faslg" RELATED Gene-based [UniProtKB:P36940] synonym: "Tnfsf6" RELATED Gene-based [UniProtKB:P36940] synonym: "rFASLG" EXACT PRO-short-label [PRO:DNx] synonym: "Apt1Lg1" RELATED Gene-based [UniProtKB:P36940] synonym: "FasL (rat)" EXACT [UniProtKB:P36940] synonym: "CD178 (rat)" EXACT [UniProtKB:P36940] synonym: "CD95-L (rat)" EXACT [UniProtKB:P36940] synonym: "Fas ligand (rat)" EXACT [UniProtKB:P36940] synonym: "CD95 ligand (rat)" EXACT [UniProtKB:P36940] synonym: "Fas antigen ligand (rat)" EXACT [UniProtKB:P36940] xref: UniProtKB:P36940 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 relationship: has_gene_template RGD:3880 ! Faslg (rat) [Term] id: PR:P41047 name: tumor necrosis factor ligand superfamily member 6 (mouse) def: "A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of mouse." [OMA:P41047, PRO:DNx] comment: Category=organism-gene. synonym: "gld" RELATED Gene-based [UniProtKB:P41047] synonym: "Fasl" RELATED Gene-based [UniProtKB:P41047] synonym: "Cd95l" RELATED Gene-based [UniProtKB:P41047] synonym: "Faslg" RELATED Gene-based [UniProtKB:P41047] synonym: "Tnfsf6" RELATED Gene-based [UniProtKB:P41047] synonym: "mFASLG" EXACT PRO-short-label [PRO:DNx] synonym: "Apt1lg1" RELATED Gene-based [UniProtKB:P41047] synonym: "FasL (mouse)" EXACT [UniProtKB:P41047] synonym: "CD178 (mouse)" EXACT [UniProtKB:P41047] synonym: "CD95-L (mouse)" EXACT [UniProtKB:P41047] synonym: "Fas ligand (mouse)" EXACT [UniProtKB:P41047] synonym: "CD95 ligand (mouse)" EXACT [UniProtKB:P41047] synonym: "Fas antigen ligand (mouse)" EXACT [UniProtKB:P41047] xref: UniProtKB:P41047 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 relationship: has_gene_template MGI:99255 ! Fasl (mouse) [Term] id: PR:000036458 name: tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hFASLG/iso:FasL/NGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000546 ! tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000036459 name: tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000034501" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P48023-1, 130-281" EXACT PRO-proteoform-std [PRO:DNx] synonym: "hFASLG/iso:FasL/Clv:soluble" EXACT PRO-short-label [PRO:DAN] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000547 ! tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form [Term] id: PR:000000277 name: tumor necrosis factor ligand superfamily member 6 isoform FasLS def: "A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41047-2 or a 1:1 ortholog thereof." [PMID:10552956, PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "FasLS" RELATED [] synonym: "FasL short" RELATED [] synonym: "FASLG/iso:FasLS" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 [Term] id: PR:000000276 name: tumor necrosis factor ligand superfamily member 6 isoform FasL def: "A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "FasL long" RELATED [] synonym: "FASLG/iso:FasL" EXACT PRO-short-label [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform 1" EXACT [PRO:DNx] is_a: PR:000000095 ! tumor necrosis factor ligand superfamily member 6 [Term] id: PR:P41047-2 name: tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasLS that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mFASLG/iso:FasLS" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P41047-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000277 ! tumor necrosis factor ligand superfamily member 6 isoform FasLS [Term] id: PR:000036782 name: tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN] comment: Category=organism-sequence. synonym: "gld" RELATED [] synonym: "hFASLG/iso:FasL/var:F273L" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P48023-1, Phe-275, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN] synonym: "FASLG isoform 1 sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "FASLG isoform FasL sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1 (human)" EXACT [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000278 ! tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L [Term] id: PR:000036783 name: tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN] comment: Category=organism-sequence. synonym: "gld" RELATED [] synonym: "mFASLG/iso:FasL/var:F273L" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P41047-1, Phe-273, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN] synonym: "Faslg isoform 1 sequence variant 1 (mouse)" EXACT [PRO:DNx] synonym: "Faslg isoform FasL sequence variant 1 (mouse)" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1 (mouse)" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1 (mouse)" EXACT [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000278 ! tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L [Term] id: PR:000000278 name: tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL that has a Leu residue at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. Example: UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:CNA, PRO:DAN] comment: Category=sequence. Note: This variation leads to an immune system phenotype with enlarged lymph nodes (MP:0000702) and increased lymphocyte cell number (MP:0005013). synonym: "gld" RELATED [] synonym: "FASLG/iso:FasL/var:F273L" EXACT PRO-short-label [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform 1 sequence variant 1" EXACT [PRO:DNx] synonym: "tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant 1" EXACT [PRO:DNx] is_a: PR:000000276 ! tumor necrosis factor ligand superfamily member 6 isoform FasL [Term] id: PR:P41047-1 name: tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse) def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mFASLG/iso:FasL" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P41047-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000276 ! tumor necrosis factor ligand superfamily member 6 isoform FasL [Term] id: PR:000000547 name: tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL that is the soluble N-terminal portion after ADAM10 processing." [PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "FASLG/iso:FasL/Clv:soluble" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000276 ! tumor necrosis factor ligand superfamily member 6 isoform FasL relationship: output_of GO:0016485 ! protein processing [Term] id: PR:000000546 name: tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 def: "A tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form that has been N-glycosylated at the Asn residues within the N-glycosylation sites located in the C-terminal extracellular region. Example: UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425] comment: Category=modification. Note: This glycosylation does not appear to be required for receptor binding or biological activity. synonym: "FASLG/iso:FasL/NGlyco:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000432 ! tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine