Protein Ontology Report - hTICAM2 PR:Q86XR7 - http://purl.obolibrary.org/obo/PR_Q86XR7

This page represents a class of proteins encompassing all the protein products of the TICAM2 gene in human .

Ontology Information
PRO ID	PR:Q86XR7 Show OBO stanza / PAF
PRO name	TIR domain-containing adapter molecule 2 (human)
Synonyms	PRO-short-label: hTICAM2 EXACT: MyD88-4 (human); TICAM-2 (human); TRIF-related adapter molecule (human); Toll-like receptor adaptor protein 3 (human); Toll/interleukin-1 receptor domain-containing protein (human); putative NF-kappa-B-activating protein 502 (human) Gene-based: TICAM2; TIRAP3; TIRP; TRAM
Definition	A TIR domain-containing adapter molecule 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q86XR7]
PRO Category	organism-gene
Parent	PR:000001750 TIR domain-containing adapter molecule 2
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 2
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:21354, UniProtKB:Q86XR7

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTICAM2 forms found in complexes

hTICAM2 Component Complexes PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000028678 ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_152149 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25867 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000028678 ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_7083 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_124855 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000027208 ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_7861 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26016 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25755 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25948 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6809 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004197 cysteine-type endopeptidase activity Reactome:REACT_151344 located_in GO:0010008 endosome membrane Reactome:REACT_151344 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_151344 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26039 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_151758 participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_151758 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26959 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_25948 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037 located_in GO:0010008 endosome membrane Reactome:REACT_124037 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_26959 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_26036 located_in GO:0010008 endosome membrane Reactome:REACT_26036 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000 located_in GO:0010008 endosome membrane Reactome:REACT_27000 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000028678 ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124037 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_6809 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_6809 GO:0034142 toll-like receptor 4 signaling pathway PR:000027208 ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000028678 ticam2:activated TLR4 complex (human) Reactome:REACT_6809 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_6809 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151758 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000027208 ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_7861 PR:000028678 ticam2:activated TLR4 complex (human) Reactome:REACT_7083 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25867 PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26036 PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26039 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124037 PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25948 PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151758 PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_27000 PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_124855 PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_25755 PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_26016 PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_152149 PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human) Reactome:REACT_151344 PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959 PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human) Reactome:REACT_26959

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