[Term]
id: PR:000001750
name: TIR domain-containing adapter molecule 2
def: "A protein that is a translation product of the human TICAM2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TIRP" RELATED Gene-based []
synonym: "TRAM" RELATED Gene-based []
synonym: "TICAM2" EXACT PRO-short-label [PRO:DNx]
synonym: "TIRAP3" RELATED Gene-based []
synonym: "TICAM-2" EXACT []
synonym: "TRIF-related adapter molecule" EXACT []
synonym: "Toll-like receptor adaptor protein 3" EXACT []
synonym: "putative NF-kappa-B-activating protein 502" EXACT []
synonym: "Toll/interleukin-1 receptor domain-containing protein" EXACT []
xref: PIRSF:PIRSF037745
is_a: PR:000000001 ! protein

[Term]
id: PR:000027201
name: TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)
def: "A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at position 2 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hTICAM2/iso:1/InitMet-/Myr:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000317689, Gly-2, MOD:00068" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027200 ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form
relationship: has_part MOD:00068 ! N-myristoylglycine

[Term]
id: PR:Q86XR7
name: TIR domain-containing adapter molecule 2 (human)
def: "A TIR domain-containing adapter molecule 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q86XR7]
comment: Category=organism-gene.
synonym: "TIRP" RELATED Gene-based [UniProtKB:Q86XR7]
synonym: "TRAM" RELATED Gene-based [UniProtKB:Q86XR7]
synonym: "TICAM2" RELATED Gene-based [UniProtKB:Q86XR7]
synonym: "TIRAP3" RELATED Gene-based [UniProtKB:Q86XR7]
synonym: "hTICAM2" EXACT PRO-short-label [PRO:DNx]
synonym: "MyD88-4 (human)" EXACT [UniProtKB:Q86XR7]
synonym: "TICAM-2 (human)" EXACT [UniProtKB:Q86XR7]
synonym: "TRIF-related adapter molecule (human)" EXACT [UniProtKB:Q86XR7]
synonym: "Toll-like receptor adaptor protein 3 (human)" EXACT [UniProtKB:Q86XR7]
synonym: "putative NF-kappa-B-activating protein 502 (human)" EXACT [UniProtKB:Q86XR7]
synonym: "Toll/interleukin-1 receptor domain-containing protein (human)" EXACT [UniProtKB:Q86XR7]
xref: UniProtKB:Q86XR7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001750 ! TIR domain-containing adapter molecule 2
relationship: has_gene_template HGNC:21354 ! TICAM2 (human)

[Term]
id: PR:Q86XR7-1
name: TIR domain-containing adapter molecule 2 isoform 1 (human)
def: "A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTICAM2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q86XR7-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027197 ! TIR domain-containing adapter molecule 2 isoform 1

[Term]
id: PR:Q86XR7-2
name: TIR domain-containing adapter molecule 2 isoform h2 (human)
def: "A TIR domain-containing adapter molecule 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86XR7-2." [PRO:DNx, UniProtKB:Q86XR7]
comment: Category=organism-sequence.
synonym: "hTICAM2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "TIR domain-containing adapter molecule 2 isoform TAG (human)" EXACT [UniProtKB:Q86XR7]
synonym: "TIR domain-containing adapter molecule 2 isoform TRAM adaptor with GOLD domain (human)" EXACT [UniProtKB:Q86XR7]
xref: UniProtKB:Q86XR7-2
is_a: PR:Q86XR7 ! TIR domain-containing adapter molecule 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000040891
name: TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
def: "A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PMID:16757566, PRO:DAN]
comment: Category=organism-modification.
synonym: "hTICAM2/iso:1/InitMet-/MyrPhos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000317689, Gly-2, MOD:00068|Ser-16, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000027200 ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00068 ! N-myristoylglycine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens