Protein Ontology Report - hIRAK1 PR:P51617 - http://purl.obolibrary.org/obo/PR_P51617

This page represents a class of proteins encompassing all the protein products of the IRAK1 gene in human .

Ontology Information
PRO ID	PR:P51617 Show OBO stanza / PAF
PRO name	interleukin-1 receptor-associated kinase 1 (human)
Synonyms	PRO-short-label: hIRAK1 EXACT: IRAK-1 (human) Gene-based: IRAK; IRAK1
Definition	An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human. [PRO:CNA]
PRO Category	organism-gene
Parent	PR:000001782 interleukin-1 receptor-associated kinase 1
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 6
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100190, HGNC:6112, Reactome:R-HSA-446639, Reactome:R-HSA-937045, Reactome:R-HSA-975127, UniProtKB:P51617

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hIRAK1 forms found in complexes
hIRAK1 Component Complexes PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000027494 hIRAK1/iso:1/Phos:1 Thr-209, MOD:00047 capable_of GO:0016301 kinase activity PMID:11960013 capable_of GO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894 PR:000027493 hIRAK1/iso:1/Phos:4 Thr-209/Thr-387, MOD:00047|MOD:00046 capable_of GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308 capable_of GO:0004674 protein serine/threonine kinase activity PMID:14625308 capable_of NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308 participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308 PR:000027492 hIRAK1/iso:1/Phos:3 Thr-209/Thr-387, MOD:00047 capable_of GO:0004674 protein serine/threonine kinase activity PMID:14625308 participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308 PR:P51617-1 hIRAK1/iso:1 capable_of GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308 capable_of GO:0005515 protein binding with PR:Q9Y4K3 hTRAF6 PMID:14625308 participates_in GO:0070498 interleukin-1-mediated signaling pathway PMID:14625308 Biological Process GO Term Protein Forms & Complexes Evidence GO:0070498 interleukin-1-mediated signaling pathway PR:000027492 hIRAK1/iso:1/Phos:3 Thr-209/Thr-387, MOD:00047 PMID:14625308 PR:000027493 hIRAK1/iso:1/Phos:4 Thr-209/Thr-387, MOD:00047|MOD:00046 PMID:14625308 PR:P51617-1 hIRAK1/iso:1 PMID:14625308 GO:0034142 toll-like receptor 4 signaling pathway PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human) Reactome:REACT_6894

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