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Protein Ontology Report - mDNAH8/iso:1

PR:Q91XQ0-1 - http://purl.obolibrary.org/obo/PR_Q91XQ0-1
Ontology Information
PRO ID PR:Q91XQ0-1 Show OBO stanza / PAF
PRO name dynein axonemal heavy chain 8 isoform 1 (mouse)
Synonyms
PRO-short-label: mDNAH8/iso:1
Definition A dynein axonemal heavy chain 8 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91XQ0-1. [PMID:12297094, PMID:16054618, PRO:KRC]
Comment Note: PMID:16054618, a combination of affinity-purified polyclonal antisera generated against epitopes from various parts of the longest possible Dnah8 coding region were used to determine that the only significant form in testis and spermatozoa is the longest form (isoform 1). Some of the profusion of mRNA species is due to variation of the 5'-UTR that does not change the coding sequence. PMID:12297094 demonstrates the existence of at least two alternatively spliced, testis-specific Dnahc8 mRNAs transcribed from both the wild type and the mutant t allele.
PRO Category organism-sequence
Parent PR:Q91XQ0 dynein axonemal heavy chain 8 (mouse)
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q91XQ0-1
mDNAH8/iso:1
located_in GO:0097228 sperm principal piece MGI:3604434, PMID:16054618
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0097228 sperm principal piece PR:Q91XQ0-1 mDNAH8/iso:1

MGI:3604434, PMID:16054618

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