back to PRO homepage

Protein Ontology Report - mDRD2/iso:2

PR:P61168-2 - http://purl.obolibrary.org/obo/PR_P61168-2
Ontology Information
PRO ID PR:P61168-2 Show OBO stanza / PAF
PRO name D(2) dopamine receptor isoform 2 (mouse)
Synonyms
PRO-short-label: mDRD2/iso:2
EXACT: D2B (mouse)
Definition A D(2) dopamine receptor isoform 2 that is encoded in the genome of mouse. [PMID:11069937, PMID:1991517, PRO:KRC]
Comment Note: PMID:1991517 shows cloning of longer cDNA for isoform 1 (aka D2A) and shows distribution of both isoform 1 and isoform 2 mRNAs within mouse tissues. PMID:11069937: Use RT-PCR to detect two forms of D2 mRNA that differ by 87 base pairs, corresponding to the two alternatively spliced isoforms of D2 mRNAs. Also detect the D2L mRNA by Northern blot from muscle striatum.
PRO Category organism-sequence
Parent PR:000037413 D(2) dopamine receptor isoform 2
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P61168-2
mDRD2/iso:2
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:892768, PMID:1991517
capable_of GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go MGI:3611062, PMID:12476322
participates_in GO:0001975 response to amphetamine MGI:3611062, PMID:12476322
participates_in GO:0042220 response to cocaine MGI:3655899, PMID:11943831
participates_in GO:0043278 response to morphine MGI:3655899, PMID:11943831
participates_in GO:0014059 regulation of dopamine secretion MGI:3655899, PMID:11943831
participates_in GO:0051967 negative regulation of synaptic transmission, glutamatergic MGI:3628700, PMID:15489038
participates_in GO:0060160 negative regulation of dopamine receptor signaling pathway MGI:2181304, PMID:11089973
participates_in GO:0032228 regulation of synaptic transmission, GABAergic MGI:3628700, PMID:15489038
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0042220 response to cocaine PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
GO:0014059 regulation of dopamine secretion PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
GO:0001975 response to amphetamine PR:P61168-2 mDRD2/iso:2

MGI:3611062, PMID:12476322
GO:0060160 negative regulation of dopamine receptor signaling pathway PR:P61168-2 mDRD2/iso:2

MGI:2181304, PMID:11089973
GO:0043278 response to morphine PR:P61168-2 mDRD2/iso:2

MGI:3655899, PMID:11943831
GO:0032228 regulation of synaptic transmission, GABAergic PR:P61168-2 mDRD2/iso:2

MGI:3628700, PMID:15489038
GO:0051967 negative regulation of synaptic transmission, glutamatergic PR:P61168-2 mDRD2/iso:2

MGI:3628700, PMID:15489038

top