Protein Ontology Report - hIgG1 PR:000050305 - http://purl.obolibrary.org/obo/PR_000050305

Ontology Information
PRO ID	PR:000050305 Show OBO stanza
PRO name	IgG1 immunoglobulin complex (human)
Synonyms	PRO-short-label: hIgG1 BROAD: IgG (human) EXACT: IgG1 (human) NARROW: IgG1 antibody (human)
Definition	An IgG immunoglobulin complex that is composed of two identical immunoglobulin heavy chains of an IgG1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG1 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, PMID:25368619, PRO:ADD]
Comment	Requested by=HIPC. Requested by=CL. Note: An IgG1 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
PRO Category	organism-complex
Parent	GO:0071735 IgG immunoglobulin complex
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-complex 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All organism-complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000050313 PR:P40259 B-cell antigen receptor complex-associated protein beta chain (human) hCD79B A B-cell antigen receptor complex-associated protein beta chain that is encoded in the genome of human. [PRO:WCB, UniProtKB:P40259] 1 PR:P11912 B-cell antigen receptor complex-associated protein alpha chain (human) hCD79A A B-cell antigen receptor complex-associated protein alpha chain that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11912] 1 PR:000050183 immunoglobulin light chain protein (human) hIgL An immunoglobulin light chain protein that is encoded in the genome of human. [PRO:DAN] 2 PR:000050301 IgG1 heavy chain protein, membrane-bound isoform (human) hIgHG1/iso:membrane-bound An IgG1 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 3' to the membrane exons. [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN] 2 PR:000050305 PR:000050183 immunoglobulin light chain protein (human) hIgL An immunoglobulin light chain protein that is encoded in the genome of human. [PRO:DAN] 2 PR:000050291 IgG1 heavy chain protein (human) hIgHG1 An IgG1 heavy chain protein that is encoded in the genome of human. [GOC:add, PRO:ADD, PRO:DAN] 2 PR:000050309 PR:000050183 immunoglobulin light chain protein (human) hIgL An immunoglobulin light chain protein that is encoded in the genome of human. [PRO:DAN] 2 PR:000050297 IgG1 heavy chain protein, secretory isoform (human) hIgHG1/iso:secretory An IgG1 heavy chain protein (human) that is a translation product of some mRNA polyadenylated at a site 5' to the membrane exons, thus preventing their incorporation the final spliced mRNA. [GOC:add, PMID:17496345, PMID:9185563, PRO:ADD, PRO:DAN] 2

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