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Protein Ontology Report - hPRKCB/iso:Beta-II/InitMet-/Phos:2

PR:000049855 - http://purl.obolibrary.org/obo/PR_000049855
Ontology Information
PRO ID PR:000049855 Show OBO stanza / PAF
PRO name protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)
Synonyms
PRO-short-label: hPRKCB/iso:Beta-II/InitMet-/Phos:2
PRO-proteoform-std: UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
Definition A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046. [PMID:8749392, PRO:KER]
Comment Evidence=(ECO:0000006, based on PMID:8749392). Kinase=("PRKCB"; PR:P05771; Thr-641/Ser-660).
PRO Category organism-modification
Parent PR:P05771-2 protein kinase C beta type isoform Beta-II (human)
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049855
hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046 		capable_of GO:0005509 calcium ion binding increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
capable_of GO:0001786 phosphatidylserine binding increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9218480
located_in GO:0005737 cytoplasm increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:9756933
participates_in GO:0006468 protein phosphorylation increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 PMID:8749392
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 		PMID:8749392
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005737 cytoplasm PR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2
Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046
increased relative to PR:000049856 hPRKCB/iso:Beta-II/InitMet-/UnPhos:2 		PMID:9756933

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