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Protein Ontology Report - hEGFR/SigPep-/Phos:3

PR:000049849 - http://purl.obolibrary.org/obo/PR_000049849
Ontology Information
PRO ID PR:000049849 Show OBO stanza / PAF
PRO name epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)
Synonyms
PRO-short-label: hEGFR/SigPep-/Phos:3
PRO-proteoform-std: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
Definition An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified to include phosphorylated serines at the C-terminal tail, at positions 1070, 1071, 1081, and 1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046. [PMID:10347170, PRO:KER]
Comment Evidence=(ECO:0000006, based on PMID:10347170). Kinase=("CAMKII"; PR:000003197; Ser-1070/Ser-1071/Ser-1081/Ser-1166). Note: Ser-1166 is the major site of phosphorylation; this phosphorylation is involved in down-regulation of kinase activity.
PRO Category organism-modification
Parent PR:000028422 epidermal growth factor receptor, signal peptide removed form (human)
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Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000049849
hEGFR/SigPep-/Phos:3
Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
capable_of GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
capable_of GO:0005515 protein binding decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 with PR:P00533 hEGFR PMID:10347170

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