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Protein Ontology Report - TIRAP:PIP2 complex

PR:000036006 - http://purl.obolibrary.org/obo/PR_000036006
Ontology Information
PRO ID PR:000036006 Show OBO stanza / PAF
PRO name TIRAP:PIP2 complex
Synonyms
BROAD: MAL:PIP2; TIRAPPIP2
Definition A macromolecular complex that is composed of TIRAP bound to phosphatydil inositol 4,5-bisphosphate. [TLR:AMM]
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 2
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000036007 PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA]
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]
PR:000036006 PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein TIRAP A protein that is a translation product of the human TIRAP gene or a 1:1 ortholog thereof. [PRO:CNA]
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]
PR:000036014 PR:P58753 Toll/interleukin-1 receptor domain-containing adapter protein (human) hTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human. [PRO:CNA]
CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000036007
TIRAP:PIP2 complex (mouse)
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway PMID:11544529
PR:000036014
TIRAP:PIP2 complex (human)
located_in GO:0005886 plasma membrane Reactome:REACT_151450
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_25222
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036007 TIRAP:PIP2 complex (mouse)

PMID:11544529
PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_25222
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036014 TIRAP:PIP2 complex (human)

Reactome:REACT_151450

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