Protein Ontology Report - AKT kinase PR:000029189 - http://purl.obolibrary.org/obo/PR_000029189

Ontology Information
PRO ID	PR:000029189 Show OBO stanza
PRO name	AKT kinase
Synonyms	BROAD: PKB EXACT: AKT; serine-threonine kinase Akt
Definition	A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites. [PMID:9736715, PRO:CNA]
PRO Category	family
Parent	PR:000000001 protein
Term Hierarchy Visualization	DAG     OLS     Cytoscape

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