[Term]
id: PR:000029189
name: AKT kinase
def: "A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [PMID:9736715, PRO:CNA]
comment: Category=family.
synonym: "AKT" EXACT []
synonym: "PKB" BROAD [PRO:DNx]
synonym: "serine-threonine kinase Akt" EXACT []
is_a: PR:000000001 ! protein