back to PRO homepage

Protein Ontology Report - ribosomal protein S6 kinase alpha

PR:000029187 - http://purl.obolibrary.org/obo/PR_000029187
Ontology Information
PRO ID PR:000029187 Show OBO stanza / PAF
PRO name ribosomal protein S6 kinase alpha
Synonyms
EXACT: MAPK-activated protein kinase-1; MAPKAP-K1; p90 ribosomal S6 kinase; p90RSK; ribosomal protein S6 kinase II
Definition A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433) and another copy of the a Protein kinase domain (Pfam:PF00069). Prototype members of this class act downstream of ERK1/2 signaling pahtway. There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations. [PMID:10411321, PRO:CNA]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000029187
ribosomal protein S6 kinase alpha
has_part Pfam:PF00069 Protein kinase domain PIRSF:PIRSF000606
has_part Pfam:PF00433 Protein kinase C terminal domain PIRSF:PIRSF000606
participates_in GO:0070371 ERK1 and ERK2 cascade PIRSF:PIRSF000606
participates_in GO:0006468 protein phosphorylation PIRSF:PIRSF000606
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000029187 ribosomal protein S6 kinase alpha

PIRSF:PIRSF000606
GO:0070371 ERK1 and ERK2 cascade PR:000029187 ribosomal protein S6 kinase alpha

PIRSF:PIRSF000606

top