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Protein Ontology Report - hTGFBR1/iso:1/SigPep-/Phos:1

PR:000025959 - http://purl.obolibrary.org/obo/PR_000025959
Ontology Information
PRO ID PR:000025959 Show OBO stanza / PAF
PRO name TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
Synonyms
PRO-short-label: hTGFBR1/iso:1/SigPep-/Phos:1
PRO-proteoform-ftid: PRO_0000024423, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PRO-proteoform-std: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
Definition A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047. [PMID:7774578, PMID:8947046]
Comment Kinase=("TGFBR2"; PR:000025962; Ser-165/Thr-185/Thr-186/Ser-187/Ser-189/Ser-191).
PRO Category organism-modification
Parent PR:000000523 TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047 		capable_of GO:0005025 transforming growth factor beta receptor activity, type I PMID:7774578, PMID:8947046
located_in GO:0005887 integral component of plasma membrane PMID:8947046
participates_in GO:0007165 signal transduction PMID:8242743
participates_in GO:0006468 protein phosphorylation PMID:7774578
participates_in GO:0007181 transforming growth factor beta receptor complex assembly PMID:8947046
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0007181 transforming growth factor beta receptor complex assembly PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8947046
GO:0006468 protein phosphorylation PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:7774578
GO:0007165 signal transduction PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8242743
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005887 integral component of plasma membrane PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
PMID:8947046

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