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Protein Ontology Report - h(LPSR:3)

PR:000025773 - http://purl.obolibrary.org/obo/PR_000025773
Ontology Information
PRO ID PR:000025773 Show OBO stanza / PAF
PRO name lipopolysaccharide receptor complex 3 (human)
Synonyms
PRO-short-label: h(LPSR:3)
BROAD: TLR4:MD2:LPS:CD14 (human)
Definition A lipopolysaccharide receptor complex 3 whose components are encoded in the genome of human. [PMID:11274165, PRO:VS]
PRO Category organism-complex
Parent PR:000025497 lipopolysaccharide receptor complex 3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape


Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000025773 PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM] 2
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480] 2
PR:000035702 CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human) hCD14/iso:1/Clv:2/anchored A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000036137
lipopolysaccharide receptor complex 3; endosome membrane (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6894
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036136
lipopolysaccharide receptor complex 3; plasma membrane (human)
located_in GO:0005886 plasma membrane Reactome:REACT_6894
participates_in GO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_6894
PR:000025773
lipopolysaccharide receptor complex 3 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)

Reactome:REACT_6809
GO:0002755 MyD88-dependent toll-like receptor signaling pathway PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)

Reactome:REACT_6894
GO:0034142 toll-like receptor 4 signaling pathway PR:000025773 lipopolysaccharide receptor complex 3 (human)

Reactome:REACT_6894
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036136 lipopolysaccharide receptor complex 3; plasma membrane (human)

Reactome:REACT_6894
GO:0010008 endosome membrane PR:000036137 lipopolysaccharide receptor complex 3; endosome membrane (human)

Reactome:REACT_6894

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