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Protein Ontology Report - TTK

PR:000016787 - http://purl.obolibrary.org/obo/PR_000016787
Ontology Information
PRO ID PR:000016787 Show OBO stanza / PAF
PRO name dual specificity protein kinase TTK
Synonyms
PRO-short-label: TTK
EXACT: ESK; Monopolar spindle protein 1; PYT; Regulatory cell proliferation kinase 1; phosphotyrosine picked threonine-protein kinase
Gene-based: MPS1; MPS1L1
RELATED: RPK1; serine/threonine-protein kinase MPS1
Definition A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 4
modification 0 organism-modification 6
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000045754
hTTK/Phos:1
Thr-676, MOD:00047 		capable_of GO:0004672 protein kinase activity PMID:18680479
participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
participates_in GO:0071174 mitotic spindle checkpoint signaling PMID:18083840
participates_in GO:0051298 centrosome duplication PMID:17728254
PR:000049844
hTTK/pActloop
capable_of GO:0004672 protein kinase activity PMID:18680479, PMID:19120698
participates_in GO:0046777 protein autophosphorylation PMID:18680479, PMID:19120698
PR:P33981
hTTK
capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 BioGRID:BG-590746
located_in GO:0000776 kinetochore PMID:20624902
participates_in GO:0051310 metaphase plate congression PMID:20624902, PMID:22732840
participates_in GO:0032092 positive regulation of protein binding PMID:22660415
participates_in GO:0032092 positive regulation of protein binding PMID:20624902
participates_in GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
participates_in GO:0031577 spindle checkpoint signaling PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:22732840
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in NOT GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902
participates_in GO:0034501 protein localization to kinetochore PMID:20624902, PMID:22732840
PR:000049845
hTTK/p(Act-loop_P+1-loop)
capable_of GO:0004672 protein kinase activity PMID:19120698
PR:P54199
yTTK
capable_of GO:0004672 protein kinase activity PMID:22521787, PMID:8688079
participates_in GO:0034501 protein localization to kinetochore PMID:22521787
participates_in GO:0031577 spindle checkpoint signaling PMID:8688079
participates_in GO:0034501 protein localization to kinetochore PMID:22521787
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0045841 negative regulation of mitotic metaphase/anaphase transition PR:P33981 hTTK

PMID:20624902
GO:0051298 centrosome duplication PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:17728254
GO:0071174 mitotic spindle checkpoint signaling PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:18083840
GO:0046777 protein autophosphorylation PR:000045754 hTTK/Phos:1
Thr-676, MOD:00047
PMID:18680479, PMID:19120698
PR:000049844 hTTK/pActloop

PMID:18680479, PMID:19120698
GO:0032092 positive regulation of protein binding PR:P33981 hTTK

PMID:22660415
PR:P33981 hTTK

PMID:20624902
NOT GO:0034501 protein localization to kinetochore PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
GO:0034501 protein localization to kinetochore PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:22732840
PR:P33981 hTTK

PMID:20624902, PMID:22732840
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902
PR:P33981 hTTK

PMID:20624902, PMID:22732840
PR:P54199 yTTK

PMID:22521787
PR:P54199 yTTK

PMID:22521787
GO:0031577 spindle checkpoint signaling PR:P33981 hTTK

PMID:20624902
PR:P54199 yTTK

PMID:8688079
GO:0051310 metaphase plate congression PR:P33981 hTTK

PMID:20624902, PMID:22732840
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:P33981 hTTK

PMID:20624902

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