[Term]
id: PR:P33981
name: dual specificity protein kinase TTK (human)
def: "A dual specificity protein kinase TTK that is encoded in the genome of human." [PMID:20823832, PRO:KER]
comment: Category=organism-gene.
synonym: "TTK" RELATED Gene-based [UniProtKB:P33981]
synonym: "MPS1" RELATED Gene-based [UniProtKB:P33981]
synonym: "hTTK" EXACT PRO-short-label [PRO:DNx]
synonym: "MPS1L1" RELATED Gene-based [UniProtKB:P33981]
synonym: "PYT (human)" EXACT [UniProtKB:P33981]
synonym: "phosphotyrosine picked threonine-protein kinase (human)" EXACT [UniProtKB:P33981]
xref: DTO:03100547
xref: UniProtKB:P33981
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016787 ! dual specificity protein kinase TTK
relationship: has_gene_template HGNC:12401 ! TTK (human)

[Term]
id: PR:000049844
name: TTK activation loop-phosphorylated form (human)
def: "A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop, at positions equivalent to Thr-675 or Thr-676 or Ser-677 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047)|Ser-677, MOD:00046." [PMID:17728254, PMID:18923149, PMID:1912069, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17728254). Evidence=(ECO:0000006, based on PMID:1912069). Evidence=(ECO:0000006, based on PMID:18923149). Kinase=("TTK"; PR:P33981; Thr-675). Kinase=("TTK"; PR:P33981; Thr-676). Kinase=("TTK"; PR:P33981; Ser-677).
synonym: "hTTK/pActloop" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047)|Ser-677, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: has_part MOD:00696 ! phosphorylated residue
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P33981-2
name: dual specificity protein kinase TTK isoform h2 (human)
def: "A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-2." [PRO:DNx, UniProtKB:P33981]
comment: Category=organism-sequence.
synonym: "hTTK/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P33981-2
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35761
name: dual specificity protein kinase TTK (mouse)
def: "A dual specificity protein kinase TTK that is encoded in the genome of mouse." [OMA:MOUSE23899, PRO:DNx]
comment: Category=organism-gene.
synonym: "Esk" RELATED Gene-based [UniProtKB:P35761]
synonym: "Ttk" RELATED Gene-based [UniProtKB:P35761]
synonym: "mTTK" EXACT PRO-short-label [PRO:DNx]
synonym: "ESK (mouse)" EXACT [UniProtKB:P35761]
synonym: "PYT (mouse)" EXACT [UniProtKB:P35761]
xref: UniProtKB:P35761
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016787 ! dual specificity protein kinase TTK
relationship: has_gene_template MGI:1194921 ! Ttk (mouse)

[Term]
id: PR:P54199
name: serine/threonine-protein kinase MPS1 (yeast)
def: "A dual specificity protein kinase TTK that is encoded in the genome of yeast." [PMID:22521787, PMID:8688079, PRO:KER]
comment: Category=organism-gene.
synonym: "MPS1" RELATED Gene-based [UniProtKB:P54199]
synonym: "RPK1" RELATED Gene-based [UniProtKB:P54199]
synonym: "yTTK" EXACT PRO-short-label [PRO:DNx]
synonym: "D2785" RELATED Gene-based [UniProtKB:P54199]
synonym: "YDL028C" RELATED Gene-based [UniProtKB:P54199]
synonym: "monopolar spindle protein 1 (yeast)" EXACT [UniProtKB:P54199]
synonym: "regulatory cell proliferation kinase 1 (yeast)" EXACT [UniProtKB:P54199]
xref: UniProtKB:P54199
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000016787 ! dual specificity protein kinase TTK
relationship: has_gene_template SGD:S000002186 ! MPS1 (yeast)

[Term]
id: PR:P33981-1
name: dual specificity protein kinase TTK isoform h1 (human)
def: "A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-1." [PRO:DNx, UniProtKB:P33981]
comment: Category=organism-sequence.
synonym: "hTTK/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P33981-1
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000016787
name: dual specificity protein kinase TTK
def: "A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ESK" EXACT []
synonym: "PYT" EXACT []
synonym: "TTK" EXACT PRO-short-label [PRO:DNx]
synonym: "MPS1" RELATED Gene-based []
synonym: "RPK1" RELATED []
synonym: "MPS1L1" RELATED Gene-based []
synonym: "Monopolar spindle protein 1" EXACT []
synonym: "serine/threonine-protein kinase MPS1" RELATED []
synonym: "Regulatory cell proliferation kinase 1" EXACT []
synonym: "phosphotyrosine picked threonine-protein kinase" EXACT []
xref: IUPHARobj:2264
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8AYG3
name: dual specificity protein kinase Ttk (zebrafish)
def: "A dual specificity protein kinase TTK that is encoded in the genome of zebrafish." [OMA:Q8AYG3, PRO:DNx]
comment: Category=organism-gene.
synonym: "ncp" RELATED Gene-based [UniProtKB:Q8AYG3]
synonym: "ttk" RELATED Gene-based [UniProtKB:Q8AYG3]
synonym: "mps1" RELATED Gene-based [UniProtKB:Q8AYG3]
synonym: "z-TTK" EXACT PRO-short-label [PRO:DNx]
synonym: "protein nightcap (zebrafish)" EXACT [UniProtKB:Q8AYG3]
synonym: "monopolar spindle protein 1 (zebrafish)" EXACT [UniProtKB:Q8AYG3]
synonym: "mitotic checkpoint serine/threonine-protein kinase Mps1 (zebrafish)" EXACT [UniProtKB:Q8AYG3]
xref: UniProtKB:Q8AYG3
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000016787 ! dual specificity protein kinase TTK
relationship: has_gene_template ZFIN:ZDB-GENE-030123-1 ! ttk (zebrafish)

[Term]
id: PR:P35761-2
name: dual specificity protein kinase TTK isoform m2 (mouse)
def: "A dual specificity protein kinase TTK (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35761-2." [PRO:DNx, UniProtKB:P35761]
comment: Category=organism-sequence.
synonym: "mTTK/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35761-2
is_a: PR:P35761 ! dual specificity protein kinase TTK (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049886
name: dual specificity protein kinase TTK isoform m2 phosphorylated 2 (mouse)
def: "A dual specificity protein kinase TTK isoform m2 (mouse) that has been phosphorylated at the position equivalent to Ser-794 of the amino acid sequence represented by UniProtKB:P35761-2. UniProtKB:P35761-2, Ser-794, MOD:00046." [PMID:21183079, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079).
synonym: "mTTK/iso:m2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35761-2, Ser-794, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P35761-2 ! dual specificity protein kinase TTK isoform m2 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049885
name: dual specificity protein kinase TTK isoform m2 phosphorylated 1 (mouse)
def: "A dual specificity protein kinase TTK isoform m2 (mouse) that has been phosphorylated at the position equivalent to Thr-402 of the amino acid sequence represented by UniProtKB:P35761-2. UniProtKB:P35761-2, Thr-402, MOD:00047." [PMID:21183079, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079).
synonym: "mTTK/iso:m2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35761-2, Thr-402, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P35761-2 ! dual specificity protein kinase TTK isoform m2 (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049884
name: dual specificity protein kinase TTK phosphorylated 1 (mouse)
def: "A dual specificity protein kinase TTK (mouse) that has been phosphorylated at positions equivalent to Thr-284 and Ser-287 of the amino acid sequence represented by UniProtKB:P35761-1. Example: UniProtKB:P35761-1, Thr-284, MOD:00047|Ser-287, MOD:00046." [PMID:21183079, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079).
synonym: "mTTK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35761-1, Thr-284, MOD:00047|Ser-287, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P35761 ! dual specificity protein kinase TTK (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P35761-1
name: dual specificity protein kinase TTK isoform m1 (mouse)
def: "A dual specificity protein kinase TTK (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35761-1." [PRO:DNx, UniProtKB:P35761]
comment: Category=organism-sequence.
synonym: "mTTK/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35761-1
is_a: PR:P35761 ! dual specificity protein kinase TTK (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049845
name: TTK activation loop and P+1 loop phosphorylated form (human)
def: "A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop and on a Thr residue in the P+1 loop. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047." [PMID:19120698, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19120698). Kinase=("TTK"; PR:P33981; Thr-675). Kinase=("TTK"; PR:P33981; Thr-676). Kinase=("TTK"; PR:P33981; Ser-677). Kinase=("TTK"; PR:P33981; Thr-686).
synonym: "hTTK/p(Act-loop_P+1-loop)" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045754
name: dual specificity protein kinase TTK phosphorylated 1 (human)
def: "A dual specificity protein kinase TTK (human) that has been phosphorylated at the position equivalent to Thr-676 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Thr-676, MOD:00047." [PMID:18083840, PMID:18680479, PMID:19120698, PRO:KER, iPTMnet:P33981]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18083840). Kinase=("TTK"; PR:P33981; Thr-676).
synonym: "hTTK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P33981-1, Thr-676, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens