| PRO ID |
PR:000003260
Show OBO stanza
|
| PRO name |
interferon regulatory factor 3 isoform 1 phosphorylated 1 |
| Synonyms |
| PRO-short-label: |
IRF3/iso:1/Phos:1 |
| EXACT: |
IRF3 active form; phospho IRF3 |
|
| Definition |
An interferon regulatory factor 3 isoform 1 phosphorylated form in which the phosphorylation occurs upon stimulation by virus infection or treatment with double-stranded RNA or LPS. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046.
[PMID:14703513, PMID:20043992, TLR:AMM]
|
| Comment |
Requested by=TLR. |
| PRO Category |
modification |
| Parent |
PR:000003259 interferon regulatory factor 3 isoform 1 phosphorylated form |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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