[Term]
id: PR:000003260
name: interferon regulatory factor 3 isoform 1 phosphorylated 1
def: "An interferon regulatory factor 3 isoform 1 phosphorylated form in which the phosphorylation occurs upon stimulation by virus infection or treatment with double-stranded RNA or LPS. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:14703513, PMID:20043992, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "phospho IRF3" EXACT []
synonym: "IRF3 active form" EXACT []
synonym: "IRF3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003259 ! interferon regulatory factor 3 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine