| PRO ID |
PR:000001975
Show OBO stanza
/ PAF
|
| PRO name |
voltage-gated sodium channel subunit alpha |
| Definition |
A voltage-gated sodium channel protein that has a core architecture consisting of four similar domains (I-VI), each containing six transmembrane helices (S1-S6), with a pore loop between S5 and S6. The S4 segments contain positively charged amino acids at every third position and serve as voltage sensors. These large proteins (about 2000 amino acids) contain a unique Sodium ion transport-associated domain (Pfam:PF06512) located between two pairs of Ion transport protein domains (Pfam:PF00520). An IQ calmodulin-binding motif (Pfam:PF00612) may be found about 100 amino acids from the carboxyl end.
[PRO:WCB]
|
| PRO Category |
family |
| Parent |
PR:000044660 voltage-gated sodium channel protein |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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