PRO ID |
PR:000001820
Show OBO stanza
/ PAF
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PRO name |
MHC class II histocompatibility antigen alpha chain |
Synonyms |
PRO-short-label: |
MHCcIIalpha |
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Definition |
A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, alpha domain (Pfam:PF00993) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region.
[PRO:WCB, Wikipedia:Human_leukocyte_antigen]
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Comment |
Note: There are three major and two minor class II MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants. In contrast to MHC Class I alpha chain genes, orthologies can be seen between some human and mouse genes. MHC class II alpha chains form heterodimers with MHLC class II beta chains. |
PRO Category |
family |
Parent |
PR:000000001 protein |
Term Hierarchy Visualization |
DAG
OLS
Cytoscape
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