| PRO ID |
PR:000001818
Show OBO stanza
/ PAF
|
| PRO name |
MHC class I histocompatibility antigen alpha chain |
| Synonyms |
| PRO-short-label: |
MHCcIalpha |
|
| Definition |
A protein with core architecture consisting of an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a cytoplasmic region containing the MHC_I C-terminus (Pfam:PF06623).
[PRO:WCB, Wikipedia:Human_leukocyte_antigen]
|
| Comment |
Note: There are three major and three minor class I MHC (major histocompatability complex) alpha chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class I loci are characterized by large numbers of allelic variants. Human and mouse genes for MHC class I histocompatibility antigen alpha chains represent independent lineage-specific expansions. MHC class I histocompatibility antigen alpha chains associate with beta-2 microglobulin to form the heterodimeric MHC antigens. |
| PRO Category |
family |
| Parent |
PR:000000001 protein |
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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