| PRO ID |
PR:000001752
Show OBO stanza
/ PAF
|
| PRO name |
NF-kappa-B essential modulator |
| Synonyms |
| PRO-short-label: |
IKBKG |
| EXACT: |
FIP-3; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; IkB kinase subunit gamma; IkB kinase-associated protein 1; NF-kappa-B essential modifier; inhibitor of nuclear factor kappa-B kinase subunit gamma |
| Gene-based: |
FIP3; NEMO |
|
| Definition |
A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression.
[PIRSF:PIRSF038160]
|
| PRO Category |
gene |
| Parent |
PR:000000001 protein |
| Terms by PRO Category |
Retrieve All terms OBO Stanza
/ PAF
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms |
|
gene
|
1 |
organism-gene
|
3 |
|
sequence
|
1 |
organism-sequence
|
3 |
|
modification
|
5 |
organism-modification
|
4 |
|
union
|
0 |
|
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