[Term]
id: PR:000001752
name: NF-kappa-B essential modulator
def: "A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160]
comment: Category=gene.
synonym: "FIP3" RELATED Gene-based []
synonym: "IKKG" EXACT []
synonym: "NEMO" RELATED Gene-based []
synonym: "FIP-3" EXACT []
synonym: "IKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKAP1" EXACT []
synonym: "IKK-gamma" EXACT []
synonym: "IkB kinase subunit gamma" EXACT []
synonym: "NF-kappa-B essential modifier" EXACT []
synonym: "I-kappa-B kinase subunit gamma" EXACT []
synonym: "IkB kinase-associated protein 1" EXACT []
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma" EXACT []
xref: PIRSF:PIRSF038160
is_a: PR:000000001 ! protein