| PRO ID |
PR:000001094
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/ PAF
|
| PRO name |
rhodopsin-like G-protein coupled receptor |
| Synonyms |
| PRO-short-label: |
fam:rhodopsin |
| EXACT: |
class 1 G-protein coupled receptor; class A G-protein coupled receptor |
|
| Definition |
A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
[PMID:12761335, PRO:DAN, PRO:WCB]
|
| Comment |
Classification based on GRAFS system. [PMID:12761335] |
| PRO Category |
family |
| Parent |
PR:000030035 G-protein coupled receptor |
| Term Hierarchy Visualization |
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