| PRO ID |
PR:000000680
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/ PAF
|
| PRO name |
transient receptor potential cation channel TRPC |
| Synonyms |
| PRO-short-label: |
fam:TRPC |
|
| Definition |
A transient receptor potential channel protein that is a member of the subfamily C of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 4 detectable copies of Ankyrin repeat (Pfam:PF00023) followed by the Transient receptor ion channel II domain (Pfam:PF08344). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means.
[PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]
|
| PRO Category |
family |
| Parent |
PR:000044657 transient receptor potential channel protein |
| Term Hierarchy Visualization |
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