| PRO ID |
PR:000000668
Show OBO stanza
/ PAF
|
| PRO name |
calcium-activated calmodulin-binding potassium channel alpha subunit |
| Definition |
A calcium-activated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. They are subunits of the small conductance calcium-activated channels. SK channels are independent of voltage and gated solely by intracellular calcium. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the calcium-binding protein calmodulin. Calmodulin binds to the SK channel through the Calmodulin binding domain (Pfam:PF02888), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when calcium binds the EF hands in the N-lobe of calmodulin. These channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable cells.
[PMID:10026195, PMID:11323678]
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| PRO Category |
family |
| Parent |
PR:000044649 calcium-activated potassium channel protein |
| Term Hierarchy Visualization |
 DAG
 OLS
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