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Protein Ontology Report - SMAD3

PR:000000365 - http://purl.obolibrary.org/obo/PR_000000365
Ontology Information
PRO ID PR:000000365 Show OBO stanza / PAF
PRO name smad3
Synonyms
PRO-short-label: SMAD3
EXACT: JV15-2; MAD homolog 3; MAD-3; SMAD 3; SMAD family member 3; mad3; mothers against DPP homolog 3
Gene-based: MADH3
Definition A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof. [PMID:9311995]
PRO Category gene
Parent PR:000000066 TGF-beta receptor-regulated smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 5
modification 6 organism-modification 8
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P84022-1
hSMAD3/iso:1
capable_of GO:0005515 protein binding with PR:O95405-1 hZFYVE9/iso:1 PMID:12154125
capable_of GO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
located_in GO:0005737 cytoplasm PMID:17074053
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
PR:000026333
hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046 		capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:15350224, PMID:9311995
capable_of GO:0008134 transcription factor binding PMID:15084259
capable_of GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886, PMID:12943993
located_in GO:0005634 nucleus PMID:10846168, PMID:15280432
part_of GO:0005667 transcription factor complex PMID:12374795
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881, PMID:9380693
participates_in GO:0006366 transcription by RNA polymerase II PMID:10823886
PR:000036558
mSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046 		capable_of GO:0003700 DNA-binding transcription factor activity PMID:10823886, PMID:12943993
capable_of GO:0008134 transcription factor binding PMID:15464984, PMID:9702197
capable_of GO:0003690 double-stranded DNA binding PMID:15282343
located_in GO:0005634 nucleus PMID:12943993, PMID:15282343
part_of GO:0005667 transcription factor complex PMID:9702197
PR:000036557
hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046 		capable_of GO:0003700 DNA-binding transcription factor activity PMID:17074756
located_in GO:0005634 nucleus PMID:17074756
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
PR:Q8BUN5-1
mSMAD3/iso:1
capable_of GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125
capable_of GO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
PR:000036561
mSMAD3/iso:1/Phos:3
Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046 		capable_of NOT GO:0003713 transcription coactivator activity PMID:10197981
located_in GO:0005737 cytoplasm PMID:10197981
PR:000036560
mSMAD3/iso:1/Phos:2
Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046 		capable_of GO:0003700 DNA-binding transcription factor activity decreased relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006366 transcription by RNA polymerase II PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:8774881, PMID:9380693
PR:000036557 hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
PMID:17074756
PR:P84022-1 hSMAD3/iso:1

PMID:8774881
PR:Q8BUN5-1 mSMAD3/iso:1

PMID:12543979
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000026333 hSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:10846168, PMID:15280432
PR:000036557 hSMAD3/iso:1/AcPhos:1
Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
Ser-423/Ser-425, MOD:00046
PMID:12943993, PMID:15282343
GO:0005737 cytoplasm PR:000036561 mSMAD3/iso:1/Phos:3
Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
PMID:10197981
PR:P84022-1 hSMAD3/iso:1

PMID:17074053

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