back to PRO homepage

Protein Ontology Report - Rho-associated protein kinase

PR:000000024 - http://purl.obolibrary.org/obo/PR_000000024
Ontology Information
PRO ID PR:000000024 Show OBO stanza / PAF
PRO name Rho-associated protein kinase
Synonyms
EXACT: RHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE (PTHR22988:SF3)
Definition A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho. [PRO:CNA]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000024
Rho-associated protein kinase
capable_of GO:0004672 protein kinase activity PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
capable_of GO:0004674 protein serine/threonine kinase activity PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
has_part Pfam:PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
has_part Pfam:PF08912 Rho Binding PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
has_part Pfam:PF00433 Protein kinase C terminal domain PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
has_part Pfam:PF00069 Protein kinase domain PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
has_part Pfam:PF00169 PH domain PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
participates_in GO:0007266 Rho protein signal transduction PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
participates_in GO:0006468 protein phosphorylation PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000000024 Rho-associated protein kinase

PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
GO:0007266 Rho protein signal transduction PR:000000024 Rho-associated protein kinase

PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568

top