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Protein Ontology Report - Myc protein

PR:000000020 - http://purl.obolibrary.org/obo/PR_000000020
Ontology Information
PRO ID PR:000000020 Show OBO stanza / PAF
PRO name Myc protein
Synonyms
BROAD: bHLH clade B; bHLH class III
Definition A protein that belongs to the clade B of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a Myc amino-terminal region (Pfam:PF01056) regulatory domain (known as TAD domain), a helix-loop-helix DNA-binding domain (Pfam:PF00010). Some members such as c-Myc contains an addition C-terminal Myc leucine zipper domain (Pfam:PF02344). Myc proteins participate in the regulation of cell proliferation, cell differentiation, and apoptosis. [PMID:16113099, PMID:16537894, PMID:16543245, PRO:CNA]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000000020
Myc protein
capable_of GO:0005515 protein binding PIRSF:PIRSF001705
capable_of GO:0003677 DNA binding PIRSF:PIRSF001705
has_part Pfam:PF01056 Myc amino-terminal region PIRSF:PIRSF001705
has_part Pfam:PF00010 Helix-loop-helix DNA-binding domain PIRSF:PIRSF001705
has_part Pfam:PF02344 Myc leucine zipper domain PIRSF:PIRSF001705
participates_in GO:0042127 regulation of cell population proliferation PIRSF:PIRSF001705
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0042127 regulation of cell population proliferation PR:000000020 Myc protein

PIRSF:PIRSF001705

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