Entry Report [PIR] - PR:000000010

Protein Ontology Report - CHRD

PR:000000010 - http://purl.obolibrary.org/obo/PR_000000010

Protein Forms Annotations

Ontology Information

PRO ID

PR:000000010 Show OBO stanza / PAF

PRO name

chordin

Synonyms

PRO-short-label:	CHRD
Gene-based:	UNQ217/PRO243

Definition

A protein that is a translation product of the human CHRD gene or a 1:1 ortholog thereof. Chordin regulates signaling by BMP pathway. [PRO:CNA]

PRO Category

gene

Parent

PR:000000001 protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
gene	1	organism-gene	6
sequence	4	organism-sequence	7
modification	3	organism-modification	3
union	0

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	PIRSF:PIRSF002496

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000036409 mCHRD/iso:1/SigPep-	capable_of	GO:0005515 protein binding	PMID:15381701
	capable_of	GO:0008201 heparin binding	PMID:15381701
	located_in	GO:0005615 extracellular space	PMID:15780974
	participates_in	GO:0030514 negative regulation of BMP signaling pathway	PMID:10479448, PMID:15780974
	participates_in	GO:0001501 skeletal system development	PMID:11784076
PR:000000087 CHRD/iso:2	has_part	NOT Pfam:PF07452 CHRD domain
PR:000000010 CHRD	capable_of	GO:0008201 heparin binding	PIRSF:PIRSF002496
	capable_of	GO:0005515 protein binding	PIRSF:PIRSF002496
	capable_of	GO:0045545 syndecan binding	PIRSF:PIRSF002496
	has_part	Pfam:PF07452 CHRD domain	PIRSF:PIRSF002496
	has_part	Pfam:PF00093 von Willebrand factor type C domain	PIRSF:PIRSF002496
	participates_in	GO:0030510 regulation of BMP signaling pathway	PIRSF:PIRSF002496
PR:000036410 frog-CHRD/iso:1/SigPep-	located_in	GO:0005615 extracellular space	PMID:8752213
PR:000036410 frog-CHRD/iso:1/SigPep-	part_of	GO:0032991 protein-containing complex	PMID:8752213
PR:000036411 mCHRD/iso:1/Clv:2	located_in	GO:0005615 extracellular space	PMID:10479448
PR:000036411 mCHRD/iso:1/Clv:2	participates_in	GO:0001501 skeletal system development	PMID:10479448
PR:Q9H2X0-1 hCHRD/iso:1	participates_in	GO:0001501 skeletal system development	PMID:9782094
PR:Q9H2X0-2 hCHRD/iso:2	participates_in	NOT GO:0030514 negative regulation of BMP signaling pathway	PMID:11472837
PR:Q9H2X0-4 hCHRD/iso:4	participates_in	GO:0030514 negative regulation of BMP signaling pathway	PMID:11472837
PR:Q9H2X0-5 hCHRD/iso:5	participates_in	GO:0030514 negative regulation of BMP signaling pathway	PMID:11472837

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0030514 negative regulation of BMP signaling pathway	PR:000036409 mCHRD/iso:1/SigPep-	PMID:10479448, PMID:15780974
	PR:Q9H2X0-4 hCHRD/iso:4	PMID:11472837
	PR:Q9H2X0-5 hCHRD/iso:5	PMID:11472837
NOT GO:0030514 negative regulation of BMP signaling pathway	PR:Q9H2X0-2 hCHRD/iso:2	PMID:11472837
GO:0001501 skeletal system development	PR:000036409 mCHRD/iso:1/SigPep-	PMID:11784076
	PR:000036411 mCHRD/iso:1/Clv:2	PMID:10479448
	PR:Q9H2X0-1 hCHRD/iso:1	PMID:9782094
GO:0030510 regulation of BMP signaling pathway	PR:000000010 CHRD	PIRSF:PIRSF002496

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000036409 mCHRD/iso:1/SigPep-	PMID:15780974
	PR:000036410 frog-CHRD/iso:1/SigPep-	PMID:8752213
	PR:000036411 mCHRD/iso:1/Clv:2	PMID:10479448

top