| Protein Ontology Report - TGF-beta-like cystine-knot cytokinePR:000000008 - http://purl.obolibrary.org/obo/PR_000000008 |
| Ontology Information | |||
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| PRO ID | PR:000000008 Show OBO stanza / PAF | ||
| PRO name | TGF-beta-like cystine-knot cytokine | ||
| Synonyms |
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| Definition | A protein with a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. [PRO:CNA] | ||
| PRO Category | family | ||
| Parent | PR:000000001 protein | ||
| Term Hierarchy Visualization |
 DAG
 OLS
Cytoscape
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| Related Cross References | |
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| DB identifiers | PIRSF:PIRSF800009 |
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Functional Annotation
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